Over the course of his college career with the California Golden Bears, Owusu played in 42 games with 18 starts from 2008 to 2011. He recorded 55 tackles, 14.0 tackles for loss (-61 yards), 8.0 sacks (-49 yards), 1 forced fumble, and 5 pass breakups. Owusu earned first-team Pac-12 All-Academic honors as a senior after being a second-team Pac-10 All-Academic selection during both sophomore and junior campaigns. He was a two-time first-team ESPN All-District® 8 pick as a junior and senior.
2007
Redshirted Owusu did not play.
2008
Owusu played in 5 games off the bench, recording 5 tackles, and 1.0 tackle for loss (-3 yards). He had a season-high 4 stops in his collegiate debut against Colorado State . Owusu’s other stop was a tackle for loss (-3 yards) in the regular-season finale vs. Washington. Owusu was second-team Pac-10 All-Academic selection.
2009
Owusu played in 12 games off the bench and finished the season with 7 tackles, a career-high 3.0 tackles for loss (-18 yards), a career-high 2.0 sacks (-15 yards) and one pass breakup. He recorded all of his sacks and tackles for loss in the season-opener vs. Maryland, with the 3.0 tackles for loss tying for the most by a Cal player in 2009 while both were career highs. Owusu had 3 tackles and his first career pass breakup vs. the Terrapins. He added two tackles in the second game of the season vs. Eastern Washington and then one each at UCLA and at Washington in the regular-season finale. Owusu was second-team Pac-10 All-Academic selection.
2010
Owusu played in all 12 games and moved into a primary starting role with starts in each of the season's first 9 games before coming off the bench in the final 3. He recorded a career-high 14 tackles, 2.5 tackles for loss (-10 yards) and 1.5 sacks (-9 yards), as well as a career-high 2 pass breakups. Owusu twice had a career-high-tying four tackles vs. Colorado and UCLA, adding 1.0 tackle for loss and 0.5 sacks for no gain vs. the Buffaloes, and 0.5 tackles for loss (-1 yard) and a quarterback hurry against the Bruins. He had a pair of tackles in back-to-back contests at Oregon State and Washington State, also picking up a sack for 9 yards against the Beavers. Owusu had single tackles vs. Arizona State and Washington, as well as a pass breakups at Nevada and vs. Oregon. He had a huge year in the classroom, earning first-team ESPN All-District® 8 and second-team Pac-10 All-Academic selections.
2011
Owusu played in all 13 games with nine starts, contributing 30 tackles to rank second among the team's defensive linemen behind Trevor Guyton. He also second on the team with 4.5 sacks (-25 yards) and fourth with 7.5 tackles for loss (-30). Owusu added a forced fumble, two pass breakups and a quarterback hurry. He had his biggest game of the season at Oregon with a career-high seven tackles, a season-high-tying 2.0 tackles for loss for a season-high 12 yards, a sack for a season-high 10 yards, a forced fumble and a pass breakup. Owusu had four tackles each at Colorado, vs. Utah and vs. Oregon State. He added a sack against both the Beavers (-9 yards) and Utes (-2 yards), as well as a total of 2.0 tackles for loss (-4 yards) against the Utes and 1.0 tackle for loss (-1 yard) against the Buffaloes. He had three tackles in the Holiday Bowl vs. Texas. Owusu had 1.5 sacks (-4 yards) against Presbyterian. His other pass breakup came in season-opener vs. Fresno State, while quarterback hurry came against USC. Owusu posted two tackles at Stanford. He had single tackles vs. Fresno State, at UCLA, vs. Washington State, and at Arizona State. Owusu picked up first-team ESPN All-District® 8 for the second consecutive year and first-team Pac-12 All-Academic honors for the first time. He earned the team's Dink Artal Award on the defensive side of the ball for the player best exemplifying Cal spirit. Owusu earned a spot on Phil Steele's midseason third-team All-Pac-12 squad.