Erasmus and two other brothers, Matthew and Oswell, studied medicine in Alabama. Dr. Matthew Burt practiced medicine in Jacksonville, Alabama, where he died in 1839. Oswell E. Burt moved to Alabama where he founded the town of Alexandria, and then moved to Texas. Erasmus Burt first practiced medicine in Calhoun county, Alabama and then moved to Mississippi.
On September 16, 1840, in Jacksonville, Alabama, Erasmus married Lucy Ann Morgan (October 22, 1821 – c. 1887), the daughter of George Washington Morgan and Mary Frances Irby. By 1845 he was practicing medicine in Oktibbeha County, Mississippi, and became a member of the House of Representatives representing Oktibbeha County, and State Auditor. While chairman of the Committee on Claims and a member of the Committee of Education he was instrumental in founding the Mississippi Institution for the Education of the Deaf and Dumb in 1854.
Civil War service
When the war broke out, Burt raised a unit for the Confederate side known as the "Burt Rifles," which became Company K of the 18th Mississippi Infantry Regiment on April 22, 1861, starting with the rank of captain. He was made a colonel on June 7, 1861. They first saw action at the First Battle of Manassas on July 21, 1861.
At the Battle of Ball's Bluff near Leesburg, Virginia, he led his men in an attack on a Unionartillery battery, but his regiment was caught in a crossfire by nearby enemy infantry. Burt was shot through his hip by a bullet which entered his stomach. His men were so enraged by his loss that they helped drive the Federals into the Potomac River where a number of them drowned. He was taken into Harrison Hall in Leesburg, Virginia. Burt was promoted to general for his bravery, but died before the promotion was received. His body was taken back to Jackson, Mississippi, where he was buried. He had eight children, and after his death his wife and younger children were moved back to Alabama by his widow's family.
Honors
There is an Erasmus Burt Award presented by the Mississippi Association of the Deaf.