Equine arteritis virus leader TRS hairpin (LTH)

Equine arteritis virus leader TRS hairpin (LTH)
Predicted secondary structure and sequence conservation of EAV_LTH
Identifiers
SymbolEAV_LTH
RfamRF00498
Other data
RNA typeCis-reg; leader
Domain(s)Viruses
SOSO:0000233
PDB structuresPDBe

The equine arteritis virus leader transcription-regulating sequence hairpin (LTH) is as RNA element that is thought to be a key structural element in discontinuous subgenomic RNA synthesis and is critical for leader transcription-regulating sequences (TRS) function.[1] Similar structures have been predicted in other arteriviruses and coronaviruses.[2]

References

  1. ^ Van Den Born E, Gultyaev AP, Snijder EJ (March 2004). "Secondary structure and function of the 5'-proximal region of the equine arteritis virus RNA genome". RNA. 10 (3): 424–437. doi:10.1261/rna.5174804. PMC 1370938. PMID 14970388.
  2. ^ Liu Y, Wimmer E, Paul AV (2009). "Cis-acting RNA elements in human and animal plus-strand RNA viruses". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1789 (9–10): 495–517. doi:10.1016/j.bbagrm.2009.09.007. PMC 2783963. PMID 19781674.
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