The New York Yankees signed Peguero as an international free agent on July 2, 2015.[1] Peguero spent the 2016 season with the Dominican Summer League Yankees. He went 2–7 with a 4.39 ERA and 43 strikeouts. Peguero was assigned to the Gulf Coast League Yankees to begin the 2017 season. After making 7 appearances, going 1–1 with an ERA of 3.00 with 5 strikeouts for the GCL Yankees, he was optioned back to the DSL Yankees, where he struggled to an 0–3 record with a 8.76 ERA with 16 strikeouts through 3 starts. Peguero spent the entire 2018 season with the GCL Yankees, where he made 9 appearances, going 0–3 with a 6.25 ERA and 23 strikeouts. Peguero spent the 2019 season with the Pulaski Yankees. He made 15 appearances for Pulaski, going 2–2 with a 4.19 ERA and 29 strikeouts. Peguero did not play in 2020 due to the COVID-19 pandemic. He began the 2021 season with the High-A Hudson Valley Renegades. He made 15 appearances for Hudson Valley, going 3–1 with a 2.51 ERA and 40 strikeouts. On July 6, 2021, Peguero was assigned to the Double-A Somerset Patriots.[2] In 6 appearances for Somerset, he went 1–0 with a 1.50 ERA and 17 strikeouts.
Los Angeles Angels
On July 30, 2021, Peguero and Janson Junk were traded to the Los Angeles Angels in exchange for Andrew Heaney.[3] The Angels assigned him to the Double-A Rocket City Trash Pandas, where he made four appearances, going 1–1 with an 8.44 ERA and eight strikeouts. On August 19, he was promoted to the Triple-A Salt Lake Bees. Peguero only made one appearance for Salt Lake, pitching two scoreless innings. On August 25, the Angels selected Peguero's contract.[4][5] He made his major-league debut on August 26 against the Baltimore Orioles, getting two outs and giving up five runs.[6] On September 17, Peguero was removed from the 40-man roster and returned to Triple-A.[7]
Peguero was re-selected to the 40-man roster following the season on November 19, 2021, to be protected from the Rule 5 draft.[8] Peguero made 13 appearances for the Angels in 2022, struggling to a 6.75 ERA with 12 strikeouts in 17.1 innings pitched. He spent the rest of his time with Triple-A Salt Lake, where he registered a 4–1 record and 2.84 ERA with 50 strikeouts and 5 saves in 38 appearances.[9]
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