Known as Murchison until 1968, it was one of the original 30 seats contested at the 1890 election. The district was located in the Western Australian outback. The seat was abolished ahead of the 1989 election.
Revived for the 2005 election, Murchison-Eyre was won by Labor candidate John Bowler, previously a member for the abolished Eyre. The district lasted one term before it was abolished ahead of the 2008 election. Its former territory was divided between the districts of Eyre, Kalgoorlie, North West, and Pilbara. Bowler, by this time an independent, successfully contested the seat of Kalgoorlie.