Edward Radclyffe, 6th Earl of Sussex (c. 1559 – August 1643) was an English politician who sat in the House of Commons between 1586 and 1611 and later succeeded to a peerage.
Radclyffe had married three times: first, Elizabeth Petre, the daughter of Sir William Petre of Ingatestone, Essex and widow of John Gostwick of Willington; secondly (1594) Jane, daughter of Francis Hynde of Madingley, Cambridgeshire and widow of John Catesby of Newnham in Goldington; and thirdly (1634) Eleanor, the daughter of Sir Richard Wortley of Wortley, Yorkshire and the widow of Sir Henry Lee, Bt., of Quarrendon, Buckinghamshire. Eleanor outlived him by many years and made two further marriages. He died impoverished and intestate. The earldom became extinct.[1]