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Eccrine nevus
Eccrine nevus
Specialty	Medical genetics

An eccrine nevus is an extremely rare cutaneous condition that, histologically, is characterized by an increase in size or number of eccrine secretory coils.^[1]^: 774 Hyperhidrosis is the most common symptom. It can present as discoloured nodules, papules, or plaques. Eccrine nevus mostly affects the extremities. Eccrine nevus are diagnosed based of histology. Treatment includes surgical excision or topical medications.

Signs and symptoms

The clinical signs of eccrine nevus might vary, involving a single nodular lesion or a broad patch encompassing the majority of the trunk.^[2] Discolored nodules, papules, and plaques may also be present. The most often reported symptom, though not always present, is hyperhidrosis.^[3] The majority of eccrine nevi are found iin the extremities, with a preference for the forearms.^[4]

Causes

The cause of eccrine nevus is uncertain.^[3] The postulated pathogenic variables include congenital abnormalities in embryogenesis, trauma, and stress, although none have been verified.^[5]

Diagnosis

Eccrine nevi are identified histologically, with findings indicating just an increase in the size and/or number of structurally normal eccrine glands. However, there have been cases reported with structural abnormalities, including adenomatous alterations, pseudobasaloid cell nests, and twisted ducts.^[6]

Treatment

The course of treatment for eccrine nevus is determined by the patient's preferences, associated symptoms, and the extent of the lesion.^[4] Surgical excision may be the best course of action when the lesion is tiny. Conversely, topical therapies such botulinum toxin or anticholinergic medicines may be used when localized hyperhidrosis coexists with a big skin lesion.^[7]

References

^ Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
^ Salama, Hania; Shwayder, Tor (2008). "Eccrine Nevus Presenting as a Hypopigmented Patch". Pediatric Dermatology. 25 (6). Wiley: 613–615. doi:10.1111/j.1525-1470.2008.00719.x. ISSN 0736-8046. PMID 19067865.
^ ^a ^b Bidari-Zerehpoosh, Farahnaz; Sabeti, Shahram; Arman, Farid; Shakeri, Hania (2017). "Eccrine Nevus Presenting with Umbilical Discharge: A Case Report and Review of the Literature". Case Reports in Dermatological Medicine. 2017. Hindawi Limited: 1–3. doi:10.1155/2017/9761843. ISSN 2090-6463. PMC 5379080. PMID 28421149.
^ ^a ^b Lee, Hanjae; Cho, Soyun (2021). "Eccrine Nevus on the Neck: A Case Report and Review of the Literature". Annals of Dermatology. 33 (5). Korean Dermatological Association and The Korean Society for Investigative Dermatology: 456–458. doi:10.5021/ad.2021.33.5.456. ISSN 1013-9087. PMC 8460470. PMID 34616127.
^ Tempark, T.; Shwayder, T. (2012-12-18). "Mucinous eccrine naevus: case report and review of the literature". Clinical and Experimental Dermatology. 38 (1). Oxford University Press (OUP): 1–6. doi:10.1111/ced.12034. ISSN 0307-6938. PMID 23252751.
^ Kang, Min Ju; Yu, Dong Soo; Kim, Jin Wou (2008). "A Case of Eccrine Nevus". Annals of Dermatology. 20 (1). Korean Dermatological Association and The Korean Society for Investigative Dermatology: 29–31. doi:10.5021/ad.2008.20.1.29. ISSN 1013-9087. PMC 4904045. PMID 27303155.
^ Christopher Kawaoka, John; Gray, Jennifer; Schappell, Deborah; Robinson-Bostom, Leslie (2004). "Eccrine nevus". Journal of the American Academy of Dermatology. 51 (2). Elsevier BV: 301–304. doi:10.1016/j.jaad.2003.12.030. ISSN 0190-9622. PMID 15280853.