The book is a fictionalized account of the last five years of Charles Dickens' life told from the viewpoint of Dickens' friend and fellow author, Wilkie Collins. The title comes from Dickens' unfinished novel, The Mystery of Edwin Drood. The novel's complex plot mixes fiction with biographical facts from the lives of Dickens, Collins, and other literary and historical figures of the Victorian era, complicated even further by the narrator's constant use of opium and opium derivatives such as laudanum, rendering him an unreliable narrator.