In 2011, after an unsuccessful trial at Corinthians,[3] Douglas was signed by Náutico. A year later, he was called up to first team.[citation needed]
On 15 February 2012, Douglas Santos made his first team debut, in a 2–0 home win over Central.[4] On the 26th, he scored his first professional goal, the second of a 3–1 home win over Belo Jardim.[5]
On 18 July, he made his Série A debut, in a 3–0 home win over Ponte Preta.[6] On 10 October, he scored his first top flight goal, in a 1–2 away defeat against Ponte Preta.[7]
Granada and Udinese
On 12 July 2013, Douglas Santos signed a five-year deal with La Liga side Granada CF, for an undisclosed fee.[8] On 2 September, he joined Udinese Calcio in a season-long loan deal.[9]
Douglas Santos made his Serie A debut on 21 December 2013, starting in a 2–1 away win against A.S. Livorno. He made two further appearances for the club during the campaign, being permanently bought by the club in January 2014.[citation needed]
Atlético Mineiro
On 12 August 2014, Douglas Santos was loaned to Atlético Mineiro for 12 months.[10] He made his debut for the club on 31 August.[citation needed]
On 20 July 2015, Galo signed Douglas Santos permanently for €3 million on a four-year contract.[11]
Hamburger SV
On 31 August 2016, Douglas Santos signed for German club Hamburger SV.[12] He played three seasons with the club, making 88 appearances and scoring three goals.[citation needed]
Zenit Saint Petersburg
On 4 July 2019, Douglas Santos joined Russian Premier League side FC Zenit Saint Petersburg, signing a five-year contract.[13][14] On 3 September 2021, he extended his Zenit contract until the end of the 2025–26 season.[15] On 25 July 2024, he extended it for the 2026–27 season, with an option for 2027–28.[16]
International career
A few months before featuring with the U-20's winning squad in the 2013 Toulon Tournament, Douglas Santos received a call-up for the full squad on 2 April 2013, for a match against Bolivia.[17] However, he did not leave the bench.[18]
On 13 August 2015, Douglas Santos returned to the senior team, for friendlies against Costa Rica and the United States.[19] He made his debut for his country in a 2016 friendly against Panama.[citation needed]
He also represented Brazil at the Rio Olympics winning the Olympic men's football tournament.[citation needed]
Personal life
On 21 October 2024, Santos acquired Russian citizenship.[20]