Discovering Dengue Drugs – Together

Discovering Dengue Drugs – Together (DDDT) was a World Community Grid project launched in 2007 sponsored by scientists at the University of Texas Medical Branch at Galveston and the University of Chicago. Its goal was to identify new antiviral drugs effective against viruses from the family Flaviviridae. The project closed in 2015.[1]

Like all World Community Grid projects, Discovering Dengue Drugs – Together used a computational grid made up of thousands of client computers belonging to independent volunteers, in conjunction with servers that distribute portions of the work to the clients.[2][3]

Phase 1

The first phase of the project launched on August 21, 2007[4] and used AutoDock 2007 (the same software used for FightAIDS@Home) to test how well antiviral drug candidates are predicted to bind to the target virus's proteases. The specific viruses targeted by the project were:[5]

Compounds predicted to bind strongly (protease inhibitors) were identified as potential antiviral drug candidates.[5] Around 2.2 million compounds were examined in Phase 1, with around 20,000 of the best scoring compounds being passed to the second phase of the project.[6]

In 2008, the project was temporarily suspended because of Hurricane Ike.[7] Processing resumed in January 2009,[8] with the server function transferred from the University of Texas Medical Branch in Galveston to the Texas Advanced Computing Center in Austin.[9] Phase 1 ended in August 2009.[10]

Phase 2

The second phase of the project was designed to reduce the number of false positive predictions made during Phase 1, using the CHARMM software package to predict how tightly small drug-like molecules bind to the different flavivirus proteases.[11]

Drug candidates that make it through Phase 2 were lab-tested, and in 2014, a novel small-molecule inhibitor of dengue virus protease was announced.[12] Phase 2 of the project was closed in March 2015.[1]

References

  1. ^ a b "Project Status | Discovering Dengue Drugs - Together | UTMB Health". 2019-01-30. Archived from the original on 2019-01-30. Retrieved 20 May 2021.
  2. ^ See "World Community Grid - About Us". Retrieved 2009-01-27.
  3. ^ See also "How Grid Computing Works". World Community Grid. Retrieved 2009-01-27.
  4. ^ "Active Research". Research. World Community Grid. Retrieved 2007-07-28.
  5. ^ a b "Discovering Dengue Drugs – Together: About the Project". World Community Grid. Retrieved 2007-08-24.
  6. ^ Tomlinson, S.; Malmstrom, R.; Watowich, S. (2009-06-01). "New Approaches to Structure-Based Discovery of Dengue Protease Inhibitors". Infectious Disorders Drug Targets. 9 (3): 327–343. doi:10.2174/1871526510909030327. PMID 19519486.
  7. ^ "Discovering Dengue Drugs Together project slowed down because of hurricane". World Community Grid ("Known Issues" forum posting).
  8. ^ "Work is being distributed for Discovering Dengue Drugs - Together". World Community Grid ("Member News" forum posting).
  9. ^ Stan Watowich (2009-01-19). "Update on Re-start". World Community Grid.
  10. ^ "World Community Grid - Research - Discovering Dengue Drugs – Together". World Community Grid.
  11. ^ "Discovering Dengue Drugs - Together - Phase 2 | Research | World Community Grid". www.worldcommunitygrid.org. Retrieved 20 May 2021.
  12. ^ Viswanathan, Usha; Tomlinson, Suzanne M.; Fonner, John M.; Mock, Stephen A.; Watowich, Stanley J. (2014-10-27). "Identification of a Novel Inhibitor of Dengue Virus Protease through Use of a Virtual Screening Drug Discovery Web Portal". Journal of Chemical Information and Modeling. 54 (10): 2816–2825. doi:10.1021/ci500531r. PMID 25263519.


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