Diagnosis: Murder's first season originally aired Fridays at 8:00-9:00 pm (EST).[1][2] The season was released on DVD by Paramount Home Video. It included the 1991 pilot "It Never Entered My Mind" from the fourth season of Jake and the Fatman.
Dr. Mark Sloan investigates the hit-and-run death of an ex-con, who was killed by his uncaught accomplice (Robert Guillaume) in his crime, who is now posing as a priest. Mark also has trouble with a homeless woman (Sylvia Sidney) who is hospitalized with an illness that resembles dementia and keeps running off, unaware she witnessed the murder.
A woman arrives at the hospital claiming to be an amnesiac, but Sloan's probing of her past leads him to discover she's a mob assassin and believe that she's plotting to murder a hospitalized senator. However, her actual target is the doctor operating on the senator, who is a witness in a case against the mob.
A millionaire dies after declaring his intention to leave his money to the hospital - and Sloan suspects the man's offspring. Note: In addition to Sloan, Dick Van Dyke plays the millionaire Johnathan Nash and his sons Julian Nash and J. Edison Nash and his daughter Judith Nash.
An infomercial financial guru arrives at Mark's house claiming to have been poisoned, dies in the living room, and disappears without a trace. His staff and his wife claim he's still alive, but make excuses as to why Mark never sees him and he suspects something's up. A side gag involves Mark diagnosing and treating a security guard at the studio who has jaw pain.
Amanda is suspected of murdering an old college roommate who had written a tell-all book about her sorority sisters. Mark believes the key to finding the true killer is locating the book before the killer does.
Note: The dog that Amanda adopts she names "Yoda".