As of the 2020 census,[4] Desoto Acres had a population of 720 with a total of 296 households. The median household income was $68,986. 30.3% of the population 25 years and older had a Bachelor's degree or higher. The CDP had an employment rate of 73.1%. 10.9% of the population lived without healthcare coverage.
†This populated place also has portions within the city limits of North Port, ‡This populated place also has portions in an adjacent county or counties