Desmond Clarke (1942–2016) was an Irish author and professor of philosophy.

Des or Desmond Clarke may also refer to:

• Desmond Clarke (writer) (1907–1979), Irish writer and librarian
• Des Clarke (comedian) (born 1981), Scottish stand-up comedian, television and radio presenter
• Des Clarke (Neighbours), a fictional character in the Australian soap opera Neighbours

• Desmond Clark (disambiguation)

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