Denise Zich grew up in Berlin. At the beginning of her career, she modeled for Calvin Klein and got her first chance as an actress in the RTL soap Gute Zeiten, schlechte Zeiten, in which she had a supporting role for several months in 1995 together with her bandmates from Just Friends. She left the band in 1996.
In 2001, Denise Zich received the Austrian television award Romy in the category Most Popular Female Shooting Star. In 2007, she appeared in the film Schwere Jungs by Marcus H. Rosenmüller. In 2010, she was a permanent member of the ensemble of the series In aller Freundschaft in her role as Dr. Isabel Dahl.
Zich lives near Berlin and has been married to her acting colleague Andreas Elsholz since 2001. They are parents of a son.[3]