Following the 2015 NFL draft, Marlowe was signed by the Carolina Panthers as an undrafted free agent.[4] He made the team's 53-man roster on September 5, 2015.[5]
On February 7, 2016, Marlowe's Panthers played in Super Bowl 50. He was inactive for the game as the Panthers fell to the Denver Broncos by a score of 24–10.[6][7]
On August 8, 2017, Marlowe was waived/injured by the Panthers and placed on injured reserve.[9] He was released on August 15, 2017.
Buffalo Bills (first stint)
On December 5, 2017, Marlowe was signed to the practice squad of the Buffalo Bills.[10] He signed a reserve/future contract with the Bills on January 8, 2018.[11]
On September 1, 2018, Marlowe was waived by the Bills and was signed to the practice squad the next day.[12][13] He was promoted to the active roster on October 6, 2018.[14] He was waived on October 9, 2018 and was re-signed to the practice squad.[15] He was promoted back to the active roster on December 12, 2018.[16]
On March 26, 2020, Marlowe re-signed with the Bills.[17] He was released as a part of final roster cuts on September 5, 2020,[18] but re-signed again the next day following some roster adjustments.[19] In Week 8 of the 2020 season against the New England Patriots, Marlowe recovered a fumble forced by teammate Justin Zimmer on Cam Newton late in the fourth quarter to secure a 24–21 Bills' win.[20] Marlowe was placed on the reserve/COVID-19 list by the team on November 14, 2020,[21] and activated on November 19.[22]
In Week 16 against the New England Patriots on Monday Night Football, Marlowe recorded his first career sack on Cam Newton during the 38–9 win.[23]
In Week 17 against the Miami Dolphins, Marlowe intercepted two passes thrown by Tua Tagovailoa during the 56–26 win.[24]
Detroit Lions
On April 8, 2021, Marlowe signed with the Detroit Lions.[25] He played in 16 games with nine starts, recording 67 tackles and two passes defensed.
Atlanta Falcons
On March 31, 2022, Marlowe signed a one-year contract with the Atlanta Falcons.[26]
Buffalo Bills (second stint)
On November 1, 2022, the Falcons traded Marlowe to the Bills in exchange for a 2023 7th-round draft pick.[27]
On May 22, 2023, Marlowe re-signed with the Bills.[28] He was released on August 29, 2023.[29]
Los Angeles Chargers
On August 31, 2023, Marlowe signed with the practice squad of the Los Angeles Chargers.[30] He was promoted to the active roster on September 30.[31]