Deadly Duo may refer to:

• The Deadly Duo, 1971 Hong Kong Wuxia film
• Deadly Duo (film), 1962 American neo noir directed by Reginald Le Borg
• "Deadly Duo", an episode of the 2019 Indian animated series Chacha Chaudhary

• The Deadly Double, a board game released in November 1941, infamous for claims that the game's advertisements contained coded messages to secret agents, giving advance notice of the Pearl Harbor attack in December 1941

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