Deadly Descent may refer to:

• Deadly Descent: The Abominable Snowman, 2013 television film

• SSX: Deadly Descents, working title for the SSX 2012 video game.
• MacGyver: Deadly Descent, video game based on the 1985 television series MacGyver

• "The Rhyme-Line Caper, Episode 5: Deadly Descent", an episode of the television series Q. T. Hush, aired in 1960
• "Chapter Five: Deadly Descent", an segment of the drama television series Cliffhangers, Stop Susan Williams story arc, aired in 1979
• "Deadly Descent", an episode of the reality television series Dr. G: Medical Examiner, aired in 2010
• "Deadly Descent", an episode of the documentary television series Alaska Wing Men, aired in 2012
• "Deadly Descent", an episode of the reality competition television series Ultimate Survival Alaska, aired in 2015
• "Deadly Descent", an episode of the documentary television series Mayday, covering Cathay Pacific Flight 780, aired in 2019

• Fortune's Deadly Descent, 2012 novel by Audrey Braun

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