DeSimone or De Simone is an Italian surname. Notable people with the surname include:

A group of related Italian American mobsters:

• Frank DeSimone, lawyer turned mobster
• Rosario DeSimone, early Los Angeles mobster
• Thomas DeSimone

• Bob DeSimone (born 1946), American actor
• Herbert F. DeSimone (1929–2013), American lawyer and politician from Rhode Island
• James DeSimone (G.I. Joe)
• Joée, born Joey DeSimone
• Joseph DeSimone (inventor)
• Louis A. DeSimone (1922–2018), American Roman Catholic bishop
• Paul DeSimone, American bodybuilder
• Robert Desimone, American neuroscientist
• Tom DeSimone (born 1939), American film director
• Vincent DeSimone (1918–1979), New Jersey detective

• Carlo De Simone (1885 – 1951), Italian army officer in World War II
• Carlo De Simone (linguist) (born 1932), Italian linguist
• Domenico de Simone (1768-1837), Italian cardinal
• Domenico De Simone (1926 – 2019), Italian politician
• Fabrizio De Simone (born 1971), Italian racing driver
• Giovanni Alfredo De Simone (1919-1985, known as Johnny Desmond), American singer
• Gustavo de Simone (born 1948), Uruguayan footballer
• Lenika de Simone (born 1985), Spanish gymnast
• Niccolò De Simone (died c. 1677), Flemish painter
• Titti De Simone (born 1970), Italian politician
• Roberto De Simone (born 1933), Italian stage director

Surname list

This page lists people with the surname DeSimone.
If an internal link intending to refer to a specific person led you to this page, you may wish to change that link by adding the person's given name(s) to the link.