David Paterson (physiologist)

David J. Paterson
MAE Hon FRSNZ
Born (1959-04-21) 21 April 1959 (age 65)
AwardsRolleston Memorial Prize (1989)
GL Brown Prize Lecture (2000)
Carl Ludwig Distinguished Lecturer (2018)
Academic background
Alma materUniversity of Otago
University of Western Australia
University of Oxford
Academic work
Sub-disciplineCardiac neurobiology

David James Paterson MAE Hon FRSNZ[1] is a New Zealand-born British physiologist and academic. He is a Fellow of Merton College, Oxford at the University of Oxford. He is also the Head of the Department of Physiology, Anatomy and Genetics at Oxford, and immediate Past President of The Physiological Society of the United Kingdom and Republic of Ireland.[2] Paterson is best known for his work in cardiac neurobiology, linking the nervous system to heart rhythm, which was featured in the 2012 BBC Four documentary Heart v Mind: What Makes Us Human?, and associated interviews on RNZ National Science programme Heart v Mind.[3] In 2018 he co-authored with Neil Herring the text book Levick's Introduction to Cardiovascular Physiology, 6th edition.[4]

Early life and education

Paterson was born in Timaru, New Zealand on 21 April 1959. He attended Otago Boys' High School and the University of Otago before training as a secondary teacher. He was awarded a Master of Science degree in 1985 from the University of Western Australia, and won a Hackett scholarship to New College, Oxford and completed a DPhil thesis, in 1989, on the control of breathing and chemoreception from the University Laboratory of Physiology. In 2005, he was awarded a Doctor of Science degree from the University of Western Australia.[citation needed]

Career

Paterson was elected to a Junior Research Fellowship at Christ Church, Oxford from 1988 to 1991. He switched fields when appointed to a British Heart Foundation Lectureship in 1991 in cardiovascular physiology at Oxford. In 1994, he was made a University Lecturer in association with a Tutorial Fellowship at Merton College, Oxford, and then, in 1998, a Reader in Physiology and in 2002, Professor of Cardiovascular Physiology. In 2016, Paterson was appointed Head of the Department of Physiology, Anatomy and Genetics at Oxford, and in 2021 unveiled the department's Statement of Inclusion in conjunction with the Equality, Diversity and Inclusion Committee. In 2018 he was made President-elect of The Physiological Society to serve as president in 2020–22.[2] Paterson was the Editor-in-Chief of Experimental Physiology from 2006 to 2011 and of The Journal of Physiology from 2011 to 2016.[5] He is a Fellow of the Royal Society of Biology and in 2014 was elected an Honorary Fellow of The Royal Society of New Zealand. In 2016 he delivered the Brookhart Award Lecture in Oregon. He was elected as an inaugural Fellow of The Physiological Society in 2017. In 2018 he delivered the Carl Ludwig Distinguished Lecture for the American Physiological Society at Experimental Biology. In 2019 he was elected a Fellow of the American Physiological Society. In 2020 he was appointed as a Core Member of the UKRI-BBSRC Bioscience Advisory Panel for an Integrated Understanding of Health Strategy and in 2021 elected a Member of Academia Europaea During 2021-22 he Chaired the controversial 10 year review of Oxford's Employer-Justified Retirement Age (EJRA). The group made wide-ranging recommendations and concluded that the EJRA was justified for some academic grades based on one of the university's legitimate Aims regarding equality and intergeneration fairness. All recommendations were accepted by Council and Congregation.[6][7] In 2023 Paterson was made an Honorary Fellow of The Physiological Society and received an Honorary degree from the University of Western Australia (Hon DUniv in Medical Sciences). In 2024 he was elected to the Academy of Fellows of the International Union of Physiological Sciences Fellows of IUPS Academy 2024

Research

Paterson is best known for his studies on potassium,[8] chemoreception[9] and respiratory control, and more recently for his discovery linking peptides and the gaseous messenger nitric oxide to cyclic nucleotide coupled cardiac autonomic neurotransmission. His work has contributed to the understanding of how the nervous system modulates cardiac excitability in health and disease.[10] Paterson leads a research team in the area of cardiac neurobiology. They are interested in how both branches of the cardiac autonomic nervous system communicate at the end organ level and established that oxidative stress plays a major role in uncoupling pre-synaptic and post synaptic signalling. The endogenous gas nitric oxide is a key intermediary in cardiac inter/intracellular signalling, where it regulates several ion channels that control cardiac excitability. His group has developed methods for targeting the enzyme involved in making nitric oxide-cGMP using a gene transfer approach involving cell specific viral vectors and FRET sensors to study the physiology of this messenger in normal and diseased hearts.[11][12]

References

  1. ^ "David Paterson, Hon Fellow, FRSNZ".
  2. ^ a b "David Paterson, President".
  3. ^ "Paterson, renowned neurobiologist, comes to Iowa". 21 November 2019.
  4. ^ "Levick's Introduction to Cardiovascular Physiology".
  5. ^ Paterson, David J. (2016). "Passing the baton". The Journal of Physiology. 594 (6): 1503–1505. doi:10.1113/JP272111. PMC 4799984. PMID 26995257.
  6. ^ "Changes to the Employer Justified Retirement Age policy".
  7. ^ "Oxford University Gazette" (PDF). Oxford University Gazette. 153 (5362). 20 October 2022.
  8. ^ Paterson, David J.; Robbins, Peter A.; Nye, Piers C. G. (1992). "Introduction: Role of Potassium in Exercise Hyperpnoea". Control of Breathing and Its Modeling Perspective. pp. 409–416. doi:10.1007/978-1-4757-9847-0_72. ISBN 978-1-4757-9849-4.
  9. ^ Paterson, David J. (2005). "Targeting Arterial Chemoreceptor Over-Activity in Heart Failure With a Gas". Circulation Research. 97 (3): 201–203. doi:10.1161/01.res.0000177931.10616.cb. PMID 16081873.
  10. ^ Li, Dan; Paterson, David J. (15 July 2016). "Cyclic nucleotide regulation of cardiac sympatho-vagal responsiveness: Cyclic nucleotide regulation of cardiac autonomic responses". The Journal of Physiology. 594 (14): 3993–4008. doi:10.1113/JP271827. PMC 4945711. PMID 26915722.
  11. ^ Wang, L.; Li, D.; Plested, C.P.; Dawson, T.; Teschemacher, A.G.; Paterson, D.J. (August 2006). "Noradrenergic neuron-specific overexpression of nNOS in cardiac sympathetic nerves decreases neurotransmission". Journal of Molecular and Cellular Cardiology. 41 (2): 364–370. doi:10.1016/j.yjmcc.2006.05.007. PMID 16806265.
  12. ^ Larsen, Hege E.; Lefkimmiatis, Konstantinos; Paterson, David J. (14 December 2016). "Sympathetic neurons are a powerful driver of myocyte function in cardiovascular disease". Scientific Reports. 6 (1): 38898. Bibcode:2016NatSR...638898L. doi:10.1038/srep38898. PMC 5155272. PMID 27966588.