Lepofsky's research centers on the indigenous peoples of the Pacific Northwest Coast and how they interacted with their environment in the past.[1] She significantly revised anthropological thinking on the historical ecology of the Northwest Coast[2] by showing that indigenous communities there have a long history of intensively managing coastal food resources.[4] In particular, she has demonstrated the antiquity of herring fishing[1][4] and clam gardens in the region, the latter going back at least 3,500 years.[5][6][7] Lepofsky's research is multidisciplinary, combining archaeology, paleoethnobotany, historical ecology, and incorporating traditional knowledge from indigenous peoples.[1]
Her work has been noted for its engagement with indigenous communities and in 2017 she received the Warren Gill Award for Community Impact from SFU. She has also served as the president of the Society of Ethnobiology and, in 2018, received the Smith-Wintemberg Award from the Canadian Archaeological Association.[2] She has been the editor-in-chief of the Journal of Ethnobiology since 2013.[1]
Quinlan, Marsha; Lepofsky, Dana, eds. (2013). Explorations in Ethnobiology: The Legacy of Amadeo Rea. Denton, TX: Society of Ethnobiology. ISBN9780988733008.