Cyclopregnol (INN), also known as neurosterone, as well as 6β-hydroxy-3:5-cyclopregnan-20-one, is a syntheticpregnanesteroid which was developed in the 1950s as a "psychotropic agent" for the treatment of mental disorders but was never marketed.[1][2][3][4] Although an initial small clinical study found effectiveness,[3] a subsequent, larger and more rigorous study found that cyclopregnol was no more effective than placebo and was clearly inferior to chlorpromazine.[4][5]
^Patel DK, Petrow V, Stuart-Webb IA (1957). "133. 6β-Hydroxy-3 : 5-cyclopregnan-20-one and some related compounds". J. Chem. Soc.: 665–668. doi:10.1039/JR9570000665. ISSN0368-1769.
^ abHardwick SW, Pearse JJ, Petrow V (October 1957). "6 beta-Hydroxy-3:5-cyclopregnan-20-one in mental states". The Journal of Mental Science. 103 (433): 835–839. doi:10.1192/bjp.103.433.835. PMID13481595.