Cyclic GMP-AMP synthase

cGAS complexed with dsDNA (based on PDB 4O6A)
Identifiers
EC no.2.7.7.86
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
cGAS dimer, human
cGAS-cGAMP-STING pathway

Cyclic GMP-AMP synthase (cGAS, cGAMP synthase), belonging to the nucleotidyltransferase family, is a cytosolic DNA sensor that activates a type-I interferon response. It is part of the cGAS-STING DNA sensing pathway. It binds to microbial DNA as well as self DNA that invades the cytoplasm, and catalyzes cGAMP synthesis.[1] cGAMP then functions as a second messenger that binds to and activates the endoplasmic reticulum protein STING to trigger type-I IFNs production.[2][3][4] Mice lacking cGAS are more vulnerable to lethal infection by DNA viruses and RNA viruses.[5][6] In addition, cGAS has been shown to be an innate immune sensor of retroviruses including HIV.[7][8] The human gene encoding cGAS is MB21D1 on chromosome 6.

References

  1. ^ Sun L, Wu J, Du F, Chen X, Chen ZJ (February 2013). "Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway". Science. 339 (6121): 786–91. Bibcode:2013Sci...339..786S. doi:10.1126/science.1232458. PMC 3863629. PMID 23258413.
  2. ^ Wu J, Sun L, Chen X, Du F, Shi H, Chen C, Chen ZJ (February 2013). "Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA". Science. 339 (6121): 826–30. Bibcode:2013Sci...339..826W. doi:10.1126/science.1229963. PMC 3855410. PMID 23258412.
  3. ^ Gao P, Ascano M, Wu Y, Barchet W, Gaffney BL, Zillinger T, et al. (May 2013). "Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase". Cell. 153 (5): 1094–107. doi:10.1016/j.cell.2013.04.046. PMC 4382009. PMID 23647843.
  4. ^ Zhang X, Shi H, Wu J, Zhang X, Sun L, Chen C, Chen ZJ (July 2013). "Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING". Molecular Cell. 51 (2): 226–35. doi:10.1016/j.molcel.2013.05.022. PMC 3808999. PMID 23747010.
  5. ^ Li XD, Wu J, Gao D, Wang H, Sun L, Chen ZJ (September 2013). "Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects". Science. 341 (6152): 1390–4. Bibcode:2013Sci...341.1390L. doi:10.1126/science.1244040. PMC 3863637. PMID 23989956.
  6. ^ Yu P, Miao Z, Li Y, Bansal R, Peppelenbosch MP, Pan Q (January 2021). "cGAS-STING effectively restricts murine norovirus infection but antagonizes the antiviral action of N-terminus of RIG-I in mouse macrophages". Gut Microbes. 13 (1): 1959839. doi:10.1080/19490976.2021.1959839. PMC 8344765. PMID 34347572.
  7. ^ Gao D, Wu J, Wu YT, Du F, Aroh C, Yan N, et al. (August 2013). "Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses". Science. 341 (6148): 903–6. Bibcode:2013Sci...341..903G. doi:10.1126/science.1240933. PMC 3860819. PMID 23929945.
  8. ^ Lahaye X, Satoh T, Gentili M, Cerboni S, Conrad C, Hurbain I, et al. (December 2013). "The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNA by the innate sensor cGAS in dendritic cells". Immunity. 39 (6): 1132–42. doi:10.1016/j.immuni.2013.11.002. PMID 24269171.

This transferase article is a stub. You can help Wikipedia by expanding it.

Read other articles:

Belgorod

Belgorod kotakota besar Белгород (ru) Bendera Belgorod coat of arms of Belgorod (en) Dinamakan berdasarkanputih dan kota Tempat categoria:Articles mancats de coordenades Negara berdaulatRusiaOblast di RusiaOblast BelgorodUrban okrug in Russia (en)Belgorod Urban Okrug (en) Ibu kota dariOblast Belgorod (1954–)Belgorod Urban Okrug (en) (2004–) NegaraRusia PendudukTotal333.931  (2023 )AgamaGereja Ortodoks Rusia GeografiLuas wilayah153,1 km² [convert: unit tak dikena...

 

Closing Bell

Closing BellGenreProgram berita bisnisPresenterMaria Bartiromo (2002-sekarang)Dylan Ratigan(2006-sekarang) Tyler Mathisen(2002-2005)Negara asal Amerika SerikatBahasa asliInggrisProduksiDurasi120 menitRilis asliJaringanCNBCRilis4 Februari 2002 –masih ditayangkan Setting penayangan Closing Bell Closing Bell adalah acara penutupan bel bisnis, yang mulai mengudara pada tanggal 4 Februari 2002 dan ditayangkan di CNBC. Tentang program Acara ini menbahas tentang penutupan bel bisnis pad...

 

Medan Maimun, Medan

Medan MaimunKecamatanIstana Maimun - Medan MaimunPeta lokasi Kecamatan Medan MaimunMedan MaimunPeta lokasi Kecamatan Medan MaimunKoordinat: 3°34′36″N 98°40′55″E / 3.576696°N 98.681973°E / 3.576696; 98.681973Koordinat: 3°34′36″N 98°40′55″E / 3.576696°N 98.681973°E / 3.576696; 98.681973Negara IndonesiaProvinsiSumatera UtaraKotaMedanPemerintahan • CamatTommy Prayoga Sidadabalok, S.STP, M.APPopulasi (202...

Olympique Lyonnais 2001-2002

Voce principale: Olympique Lyonnais. Olympique LyonnaisStagione 2001-2002Sport calcio Squadra Olympique Lione Allenatore Jacques Santini All. in seconda Dominique Cuperly Presidente Jean-Michel Aulas Division 11º (in Champions League) Coupe de FranceSedicesimi di finale Coupe de la LigueOttavi di finale Champions LeagueFase a gironi Coppa UEFAOttavi di finale Maggiori presenzeCampionato: Coupet (34)Totale: Coupet (48) Miglior marcatoreCampionato: Anderson (14)Totale: Anderson (18) Stad...

 

1582 Cagayan battles

Combats of Spanish soldiers against Japanese samurai pirates in the Philippines 1582 Cagayan battlesDate1582LocationCagayan, Luzon, PhilippinesResult Spanish victoryBelligerents Spanish Empire Spanish Philippines WokouCommanders and leaders Juan Pablo de Carrión Pedro Lucas  † Tay Fusa[1]Strength 60 soldiers20 sailors[2]unknown number of native allies and ships1 galleon5 small vessels 1 light vessel[1] 1 junk18 sampans<100 Wako pirates[1]Casualt...

 

Чайки

У этого термина существуют и другие значения, см. Чайки (значения). Чайки Доминиканская чайкаЗападная чайкаКалифорнийская чайкаМорская чайка Научная классификация Домен:ЭукариотыЦарство:ЖивотныеПодцарство:ЭуметазоиБез ранга:Двусторонне-симметричныеБез ранга:Вторич...

Mark Ramprakash

Former English cricketer This article is about the former English cricketer. For the retired Indian cricketer, see B. Ramprakash. Mark RamprakashMBEPersonal informationFull nameMark Ravin RamprakashBorn (1969-09-05) 5 September 1969 (age 54)Bushey, Hertfordshire, EnglandNicknameRamps, Bloodaxe, The Hips, TwentiesHeight5 ft 10 in (1.78 m)BattingRight-handedBowlingRight arm off-spinRoleBatsmanInternational information National sideEnglandTest debut (cap 549)6 J...

 

Versutoxin

Spider toxin Delta Hexatoxin Hv1a3D stick model of delta-hexatoxin-Hv1 (versutoxin)IdentifiersSymbolδ-HXTX-Hv1aPfamPF05353InterProIPR008017OPM superfamily112OPM protein1vtxAvailable protein structures:Pfam  structures / ECOD  PDBRCSB PDB; PDBe; PDBjPDBsumstructure summary Delta hexatoxin Hv1 (δ-HXTX-Hv1a, Versutoxin, or Versutotoxin, formerly known as Delta atracotoxin Hv1 and δ-ACTX-Hv1a)[1] is a neurotoxic component found in the venom of the Australian funnel web spider...

 

MTV3

Questa voce sull'argomento Eurovisione è solo un abbozzo. Contribuisci a migliorarla secondo le convenzioni di Wikipedia. Segui i suggerimenti del progetto di riferimento. MTV3 Paese  Finlandia Lingua finlandese Tipo generalista Nomi precedenti MTV (Mainostelevisio)(1957-1993) Data di lancio 13 agosto 1957 Share 22.9% (2008, [1]) Editore Bonnier Group Sito www.mtv3.fi Gli studi di MTV3 ad Vallila, Helsinki MTV3 è una rete televisiva privata finlandese di proprietà del gr...

Vincenzo Sarno (calciatore)

Vincenzo Sarno Nazionalità  Italia Altezza 167 cm Calcio Ruolo Attaccante Squadra  Real Casalnuovo CarrieraGiovanili 1999 Torino1999-2002 Gaetano Scirea2002-2005 RomaSquadre di club1 2005-2007 Sangiovannese18 (1)[1]2007→  Giulianova14 (0)2007-2008 Sangiovannese5 (0)2008 Brescia2 (0)2008-2009 Potenza22 (1)2009-2011 Pro Patria40 (7)[2]2011-2012 Reggina7 (0)[3]2012→  Virtus Lanciano11 (0)[4]2012-201...

 

Stefanus

Halaman ini berisi artikel tentang Nathan Vincetio H, salah seorang diakon Gereja Perdana. Untuk Santo Stefanus, Raja Hungaria pertama, lihat István I dari Hungaria. Untuk tokoh lain dengan nama yang sama, lihat Stefanus (disambiguasi). StefanusSanto Stefanus karya Carlo CrivelliDiakon dan ProtomartirLahirca. 5 MMeninggalca. 34 MYerusalem, Provinsi Yudea, Kekaisaran RomawiDihormati diGereja Katolik RomaGereja Katolik TimurGereja Ortodoks TimurGereja Ortodoks OrientalGereja Timur AsiriaGereja...

 

哥伦布 (密西西比州)

密西西比州 哥伦布城市綽號：Possum Town哥伦布位于密西西比州的位置坐标：33°30′06″N 88°24′54″W / 33.501666666667°N 88.415°W / 33.501666666667; -88.415国家 美國州密西西比州县朗兹县始建于1821年政府 • 市长罗伯特·史密斯 (民主党)面积 • 总计22.3 平方英里（57.8 平方公里） • 陸地21.4 平方英里（55.5 平方公里） • ...

List of Atlético Madrid managers

Diego Simeone is the most successful Atlético Madrid manager, with eight honours. This is a list of all former coaches of Atlético Madrid. Current coach Diego Simeone took over from Gregorio Manzano on 23 December 2011. Managers As of match played 24 September 2023 Manager Nationality From To M W D L GF GA Win%[1] Honours Notes Manuel Ansoleaga Spain 1921 1922 (n/a) (n/a) (n/a) (n/a) (n/a) (n/a) (n/a) 1 Campeonato Regional Centro Urbano Iturbe Spain 1922 1923 (n/a) (n/a) (n/a) (n/a...

 

Saraburi United F.C.

Thai football club This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Saraburi United F.C. – news · newspapers · books · scholar · JSTOR (October 2015) (Learn how and when to remove this message) Football clubSaraburi Unitedสระบุรี ยูไนเต็ดFull nameSaraburi United Football ClubNick...

 

KKXX-FM

Radio station in Shafter, CaliforniaKKXX-FMShafter, CaliforniaBroadcast areaBakersfield, CaliforniaFrequency93.1 MHzBrandingHits 93.1ProgrammingFormatTop 40 (CHR)OwnershipOwnerAmerican General MediaSister stationsKEBT, KERN, KGEO, KGFM, KISVHistoryFirst air date1990 (as KXHA)Former call signsKXHA (10/17/90-4/8/95)KLYD (4/8/95-7/8/97)KSAN (7/8/97-12/11/97)KCOO (12/11/97-3/20/02)KRFR (3/20/02-9/20/04)[1]Technical informationFacility ID35953ClassAERP4,000 wattsHAAT123 meters (404 feet)Tr...

طماطم

اضغط هنا للاطلاع على كيفية قراءة التصنيف الطماطم مقطع طولي وقطعة كاملة من الطماطم حالة الحفظ أنواع غير مهددة أو خطر انقراض ضعيف جدا المرتبة التصنيفية نوع[1][2]  التصنيف العلمي المملكة: النباتات الطائفة: ثنائيات الفلقة الرتبة: باذنجانيات الفصيلة: باذنجانية الجنس: ...

 

ニシノフラワー

この記事は「旧馬齢表記」が採用されており、国際的な表記法や2001年以降の日本国内の表記とは異なっています。 詳しくは馬齢#日本における馬齢表記を参照してください。ニシノフラワー[1]欧字表記 Nishino Flower[1]品種 サラブレッド[1]性別 牝[1]毛色 黒鹿毛[1]生誕 1989年4月19日[2][1]死没 2020年2月5日（31歳没）[3]父 マジェス�...

 

Diavolo

Disambiguazione – Se stai cercando altri significati, vedi Diavolo (disambigua). Disambiguazione – Diavoli rimanda qui. Se stai cercando altri significati, vedi Diavoli (disambigua). Il diavolo Lucifero immobilizzato al centro del Cocito, enorme lago ghiacciato situato sul fondo dell'Inferno della Divina Commedia (illustrazione di Gustave Doré) Nelle religioni il diavolo (o demonio o maligno) è un'entità spirituale o soprannaturale essenzialmente malvagia, distruttrice, menzog...

Invention

Novel device, material or technical process Invented, Inventing, and Inventive redirect here. For other uses, see Invention (disambiguation) and Inventor (disambiguation). 'BUILD YOUR OWN TELEVISION RECEIVER.' Science and Invention magazine cover, November 1928 An invention is a unique or novel device, method, composition, idea or process. An invention may be an improvement upon a machine, product, or process for increasing efficiency or lowering cost. It may also be an entirely new concept. ...

 

Collective leadership in the Soviet Union

Form of governance in the USSR Politics of the Soviet Union   Leadership Leaders President list Vice President Collective leadership State Council Presidential Council Communist Party Congress Central Committee History General Secretary Politburo Secretariat Orgburo Legislature Congress of Soviets Central Executive Committee Supreme Soviet Soviet of the Union Soviet of Nationalities Presidium Congress of People's Deputies Speaker 1989 Legislative election Governance Constitution Official...