During the first two years of First World War, he ran Germany's espionage, propaganda and sabotage operations in the Ottoman territories of Palestine, Lebanon and Syria in preparation for the two Turco-German attacks on the Suez Canal in Sinai in 1915 and 1916. During the summer of 1916, he served as an aerial intelligence observer with the German air unit Fliegerabteilung (Flight Detachment) 300 in southern Palestine and Sinai. His two years of service left him in ill health, so he returned to Berlin in September 1916, after which he returned to Constantinople in April 1917 as head of Germany's propaganda operation in the Middle East. He finished out the war as the government minder for Abbas II of Egypt, that country's former khedive, or ruler, during the latter's visit to Germany and Belgium.
From 1930 to 1936 Prüfer worked for the government administration in Berlin as Deputy Head of Anglo-America and the Orient. From 1936 to 1939, he was head of the Foreign Office on Wilhelmstrasse. In December 1937 he joined the Nazi Party, and was tasked with removing officials with Jewish ancestry and wives. Early in the Second World War, Prüfer was sent to Brazil to confer with PresidentGetúlio Vargas. By mid-1943 he had returned to the Reich and was promoted to head of the Oriental Department of the Ministry of Foreign Affairs, and directly oversaw the Grand Mufti of Jerusalem Haj Amin al-Husseini. In September 1943 Prüfer moved with his family to Switzerland.
In October 1948, Prüfer became Chair of International Relations at Delhi University, the first such position in India.[1]
Maria Keipert (Red.): Biographisches Handbuch des deutschen Auswärtigen Dienstes 1871–1945. Herausgegeben vom Auswärtigen Amt, Historischer Dienst. Band 3: Gerhard Keiper, Martin Kröger: L–R. Schöningh, Paderborn u. a. 2008, ISBN978-3-506-71842-6.
Donald M. McKale, Rewriting History: The Original & Revised World War II Diaries of Curt Prüfer, Nazi Diplomat. Kent State University Press, Ohio 1989. ISBN978-0-87338-364-6
Donald M. McKale, Curt Prüfer: German Diplomat from the Kaiser to Hitler. Kent State University Press, Ohio 1987, ISBN978-0-87338-345-5
Kevin Morrow (ed.): Germany's Covert War in the Middle East: Espionage, Propaganda and Diplomacy in World War I. I.B. Taurus, London, UK, 2018. ISBN978-1-78453-143-0