PROFILPELAJAR.COM

Cryptide

For similar terms, see Cryptide (disambiguation).

A cryptide, also known as cryptein or cryptic peptide, is a bioactive peptide produced by proteolytic cleavage of a larger precursor protein, whose biological activity is distinct from that of the parent protein.[1] Cryptides are involved in the modulation of a variety of biological processes, including neuronal signaling, angiogenesis, immune and inflammatory responses, and cell growth.[2] These peptides have attracted some interest in pharmacological research.

Terminology

The term cryptide refers to a bioactive peptide produced by proteolytic cleavage of a larger precursor protein, while crypteins are cryptic proteins generated through similar mechanisms. Cryptides are conceptually part of the broader "cryptome", a subset of the proteome composed of proteins that can yield bioactive fragments upon fragmentation.[1][3] Their study en mass is known as cryptomics.[4]

Examples

Examples of cryptides include:

See also

References

  1. ^ a b Pimenta, Daniel C; Lebrun, Ivo (2007). "Cryptides: Buried secrets in proteins". Peptides. 28 (12): 2403–2410. doi:10.1016/j.peptides.2007.10.005. PMID 18023928.
  2. ^ Ner, Joanna; Kotlinska, Jolanta H; Silberring, Jerzy (2015). "Crypteins--an overlooked Piece of Peptide Systems". Current Protein & Peptide Science. 16 (3): 203–218. doi:10.2174/1389203716666150224125557. PMID 25707474.
  3. ^ Gaglione, Rosa; Pizzo, Elio; Notomista, Eugenio; de la Fuente-Núñez, César; Arciello, Angela (2020). "Host Defence Cryptides from Human Apolipoproteins: Applications in Medicinal Chemistry". Current Protein & Peptide Science. 20 (14): 1324–1337. doi:10.2174/1568026620666200427091454. PMID 32338222.
  4. ^ a b c Samir, Parimal; Link, Andrew J. (2011). "Analyzing the Cryptome: Uncovering Secret Sequences". AAPS Journal. 13 (2): 152–158. doi:10.1208/s12248-011-9252-2. PMC 3085711. PMID 21327597.
  5. ^ Mukai, Hidehito; Hokari, Yoshinori; Seki, Tetsuo (2008). "Discovery of Mitocryptide-1, a Neutrophil-activating Cryptide from Healthy Porcine Heart". Journal of Biological Chemistry. 283 (45): 30596–30605. doi:10.1074/jbc.M803913200. PMC 2662150. PMID 18768476.
  6. ^ Mukai, Hidehito; Seki, Tetsuo; Nakano, Hiroko; Hokari, Yoshinori; Takao, Toshifumi (2009). "Mitocryptide-2: purification, identification, and characterization of a novel cryptide that activates neutrophils". Journal of Immunology. 182 (8): 5072–5080. doi:10.4049/jimmunol.0802965. PMID 19342687.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.