Columbia Southern may refer to:

• Columbia-Southern Chemical Corporation, a heavy industrial chemical company
• Columbia Southern Hotel, a historic Oregon hotel
• Columbia Southern Railway, an Oregon rail line
• Columbia Southern Railway Passenger Station and Freight Warehouse, a historic Oregon building
• Columbia Southern University, an Alabama for-profit private university specializing in distance education

• British Columbia Southern Interior, a former British Columbia, Canada electoral district
• British Columbia Southern Railway, a railway stretching through parts of Canada and the United States
• All pages with titles beginning with Columbia Southern
• All pages with titles containing Columbia Southern

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