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COLEC12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OX8
Identifiers
Aliases	COLEC12, CLP1, NSR2, SCARA4, SRCL, collectin subfamily member 12
External IDs	OMIM: 607621; MGI: 2152907; HomoloGene: 34248; GeneCards: COLEC12; OMA:COLEC12 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	500,722 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	9,882,644 bp
RNA expression pattern
	Top expressed in
	synovial joint; ; tibia; ; synovial membrane; ; tendon of biceps brachii; ; retinal pigment epithelium; ; placenta; ; skin of hip; ; periodontal fiber; ; pericardium; ; cartilage tissue;
	Top expressed in
	basilar part of occipital bone; ; mesothelium of peritoneum; ; sphenoid bone; ; calvaria; ; basisphenoid; ; pericardium; ; vestibular sensory epithelium; ; external carotid artery; ; rib; ; pleura;
	More reference expression data
	n/a
Gene ontology
Molecular function	pattern recognition receptor activity; galactose binding; metal ion binding; low-density lipoprotein particle binding; scavenger receptor activity; carbohydrate binding;
Cellular component	integral component of membrane; endocytic vesicle membrane; collagen; membrane; plasma membrane; extracellular space; extracellular matrix;
Biological process	defense response; positive regulation of cell adhesion molecule production; carbohydrate mediated signaling; receptor-mediated endocytosis; immune response; cellular response to exogenous dsRNA; phagocytosis, recognition; innate immune response; toll-like receptor 3 signaling pathway; protein homooligomerization; regulation of immune response;
	Sources:Amigo / QuickGO
Orthologs
	81035
	140792
	ENSG00000158270
	ENSMUSG00000036103
	Q5KU26
	Q8K4Q8
	NM_030781; NM_130386
	NM_130449
	NP_569057
	NP_569716
	Wikidata
View/Edit Human	View/Edit Mouse

Collectin-12, also known as collectin subfamily member 12, is a collectin protein that in humans is encoded by the COLEC12 gene.^[5]

Function

This gene encodes a member of the collectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells. [provided by RefSeq, May 2018].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000158270 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036103 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Collectin subfamily member 12". Retrieved 2019-12-24.

Ohmori H, Makita Y, Funamizu M, Chiba S, Ohtani K, Suzuki Y, Wakamiya N, Hata A (2003). "Haplotype analysis of the human collectin placenta 1 (hCL-P1) gene". J. Hum. Genet. 48 (2): 82–5. doi:10.1007/s100380300011. PMID 12601552.
Yoshida T, Tsuruta Y, Iwasaki M, Yamane S, Ochi T, Suzuki R (March 2003). "SRCL/CL-P1 recognizes GalNAc and a carcinoma-associated antigen, Tn antigen". J. Biochem. 133 (3): 271–7. doi:10.1093/jb/mvg037. PMID 12761161.
Coombs PJ, Graham SA, Drickamer K, Taylor ME (June 2005). "Selective binding of the scavenger receptor C-type lectin to Lewisx trisaccharide and related glycan ligands". J. Biol. Chem. 280 (24): 22993–9. doi:10.1074/jbc.M504197200. hdl:11858/00-001M-0000-0011-5639-F. PMID 15845541.
Selman L, Skjodt K, Nielsen O, Floridon C, Holmskov U, Hansen S (June 2008). "Expression and tissue localization of collectin placenta 1 (CL-P1, SRCL) in human tissues". Mol. Immunol. 45 (11): 3278–88. doi:10.1016/j.molimm.2008.02.018. PMID 18423602.
Jang S, Ohtani K, Fukuoh A, Yoshizaki T, Fukuda M, Motomura W, Mori K, Fukuzawa J, Kitamoto N, Yoshida I, Suzuki Y, Wakamiya N (February 2009). "Scavenger receptor collectin placenta 1 (CL-P1) predominantly mediates zymosan phagocytosis by human vascular endothelial cells". J. Biol. Chem. 284 (6): 3956–65. doi:10.1074/jbc.M807477200. PMID 19073604.
Samsen A, Bogoevska V, Klampe B, Bamberger AM, Lucka L, Horst AK, Nollau P, Wagener C (January 2010). "DC-SIGN and SRCL bind glycans of carcinoembryonic antigen (CEA) and CEA-related cell adhesion molecule 1 (CEACAM1): recombinant human glycan-binding receptors as analytical tools". Eur. J. Cell Biol. 89 (1): 87–94. doi:10.1016/j.ejcb.2009.11.018. PMID 20034698.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M (April 2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Graham SA, Antonopoulos A, Hitchen PG, Haslam SM, Dell A, Drickamer K, Taylor ME (July 2011). "Identification of neutrophil granule glycoproteins as Lewis(x)-containing ligands cleared by the scavenger receptor C-type lectin". J. Biol. Chem. 286 (27): 24336–49. doi:10.1074/jbc.M111.244772. PMC 3129213. PMID 21561871.