In 2017, Ponce played for both the Carolina Mudcats of the Class A-Advanced Carolina League, and the Biloxi Shuckers of the Class AASouthern League,[10] posted a combined 10–9 record with a 3.14 ERA over 25 starts.[11] He spent the 2018 season with Biloxi, going 7–6 with a 4.36 ERA in 29 games (11 starts). In 2019, he returned to Biloxi to begin the season.[12]
Ponce made his major league debut on August 2, 2020 against the Chicago Cubs and was the losing pitcher.[citation needed] He had an 0–6 record and a 7.04 ERA in 38+1⁄3 innings in 15 games for the Pirates in 2021, while spending the rest of the season with Indianapolis. After the 2021 season, on November 29, 2021, the Pirates released Ponce to allow him to play in Japan.[17]
Hokkaido Nippon-Ham Fighters
On December 5, 2021, Ponce signed with the Hokkaido Nippon-Ham Fighters of Nippon Professional Baseball (NPB).[18] On August 27, 2022, Ponce pitched a no-hitter against the Fukuoka SoftBank Hawks in Sapporo Dome, making himself the seventh foreign-born player to achieve it after the NPB introduced the 2-league system when it was reorganized from the JBL in the 1950 season.[19] He finished the year appearing in 14 games, logging a 3–5 record and 3.35 ERA with 66 strikeouts in 83+1⁄3 innings pitched.
On April 5, 2023, Ponce was diagnosed with a partially torn quadriceps tendon in his left leg that would sideline him for 4 weeks.[20] In 10 games for the team, he registered a 4–5 record and 3.66 ERA with 43 strikeouts across 51+2⁄3 innings. On November 27, it was announced that Ponce and the Fighters could not reach a contract agreement, making him a free agent.[21]
Tohoku Rakuten Golden Eagles
On December 26, 2023, Ponce signed with the Tohoku Rakuten Golden Eagles of Nippon Professional Baseball.[22] He made 15 appearances for the Eagles in 2024, struggling to a 3–6 record and 6.72 ERA with 56 strikeouts across 67 innings pitched. On December 2, 2024, the Eagles announced that Ponce would not be brought back in 2025, making him a free agent.[23]