After signing, Seise was assigned to the rookie–level AZL Rangers. There, he posted a .336 batting average with three home runs and 27 RBI in 27 games which earned him a promotion to the Low–A Spokane Indians, where he batted .222 with nine RBI in 24 games to end his first professional season.[5] He missed all of 2018 after undergoing rotator cuff surgery.[6] Seise was assigned to the Hickory Crawdads of the Single–ASouth Atlantic League to open the 2019 season,[7] and appeared in 21 games, hitting .241/.267/.356 with 6 RBI.[8] Seise underwent surgery in early May to repair a torn labrum in his left shoulder and missed the rest of the 2019 season.[9][10]
Seise did not play in a game in 2020 due to the cancellation of the minor league season because of the COVID-19 pandemic. Seise was assigned to the Hickory Crawdads of the High-A East to open the 2021 season.[11] After just 10 games in 2021, Seise tore the ACL in his right knee, which required season-ending surgery to repair.[12][13] Seise returned to Hickory for the 2022 season, hitting .246/.319/.384 with 10 home runs, 46 RBI, and 12 stolen bases.[14]
Seise opened the 2023 season with the Frisco RoughRiders of the Double-ATexas League. In 91 games for Frisco, he batted .211/.280/.311 with four home runs, 39 RBI, and 14 stolen bases. Seise elected free agency following the season on November 6, 2023.[15]