Castanho left the band in 2001, after the release of their third album Nadando com os Tubarões, and they continued as a quartet until Tamo Aí na Atividade, when a series of creative divergences prompted the departure of its entire line-up.[3] After a brief hiatus, Chorão reactivated the band in 2005 with Heitor Gomes on bass, André Pinguim on drums and Castanho returning as guitarist.[4] Pinguim's contract expired in 2008, after which he was replaced by Bruno Graveto, and in 2011, following the departure of Gomes, Champignon and Marcão Britto returned to make Charlie Brown Jr. a quintet again.[5]
While the band was working on their tenth studio album, La Familia 013, Chorão, who had always struggled with substance abuse, died due to a cocaine overdose on March 6, 2013, effectively ending the group's activities.[6] Six months later, on September 9, Champignon committed suicide by firearm following increasing bouts of anxiety and depression.[7] The album, eventually their last, was released posthumously on October 8.
On July 13, 2021, the live album Chegou Quem Faltava, originally recorded during a 2011 show, received a posthumous release through Sony Music.[8]