After his college career, the 6'10", 245 lb. power forward was selected third overall in the 1988 NBA draft by the Philadelphia 76ers but immediately traded to the Los Angeles Clippers. He made the 1988 NBA All-Rookie Team by averaging 16 points and 8 rebounds. During his four years with the Clippers he was the team's top scorer averaging 19 points per game. He was later traded to the New York Knicks with Doc Rivers and Bo Kimble for point guardMark Jackson. Smith was expected to fill the hole at small forward left by Xavier McDaniel after the Knicks failed to re-sign him after their successful 1991–92 season, a role that Smith struggled in as he was primarily a power forward. His knees became more problematic playing small forward around this time. As Smith's stats declined, he was traded to the San Antonio Spurs for J. R. Reid before retiring in 1998.
Post-retirement
Smith is a Resource Board Member of Family Office Association developing global partnerships. Prior, he was Head of Sports & Entertainment MediaCom and Head of New Business for Midas Exchange, both owned by WPP/GroupM.
After retiring from the NBA, Smith served as Team Representative for the National Basketball Players Association (NBPA) and then as First Vice President. Smith helped create the NBPA Foundation, a non-profit to support retired players in need. Smith went on to serve as Executive Director of the National Basketball Retired Players Association (NBRPA). Smith produced and executed exhibition games featuring over 40 retired NBA players.
Smith was founder and CEO of New Media Technology Corp. The company was the first to develop and patent customizable applications for video ingestion in 1998.
Today, Charles D. Smith founded a construction company in Africa to develop sports and entertainment communities similar to LA Live in Los Angeles and Deer Park in Milwaukee.