After moving to Georgetown, Mix entered the mercantile business.[2] His business failed during the Panic of 1837.[1]
In 1838, Mix was appointed by President Martin Van Buren as a clerk in the Bureau of Indian Affairs. He was later appointed as chief clerk, under Secretary of the Interior Thomas Ewing, in November 1850.[1][2][3] While chief clerk, Mix drafted the Yankton Treaty of April 19, 1858, with the Yankton Sioux Tribe. He was also known for drafting the 1850 Office Copy of the Laws, Regulations, Etc., an important set of regulations for implementing and governing Indian affairs.[1] He served as acting commissioner in August 1853 and June 1856 while George Washington Manypenny was traveling in Nebraska and on temporary absence, respectively.[4][5] He again served as acting commissioner in April 1857 after the resignation of Manypenny.[6] He was appointed as commissioner of Indian Affairs, after the resignation of James W. Denver, serving from June 14, 1858 to November 8, 1858. Mix resigned, preferring to work behind the scenes.[1][7] Mix retired from the Bureau of Indian Affairs in 1869.[1]
Personal life
Mix married Catharine Upperman, of Georgetown, in 1829. They had five sons and four daughters.[2]
Mix died on January 15, 1878, at his home at 164 High Street in Georgetown.[8] He is interred at Oak Hill Cemetery in the Georgetown neighborhood of Washington, D.C., along with his wife and children.[9][10]
^"Charles Mix County". About South Dakota: County of the Month. Office of U.S. Senator Tim Johnson (SD). Archived from the original on June 9, 2010. Retrieved June 4, 2010.
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