The Central Lakeshore Conference is a former high school athletic conference in east central Wisconsin. It was operational from 1969 to 2015 and all member schools (with the exception of one) were members of the Wisconsin Interscholastic Athletic Association.

The Central Lakeshore Conference was formed in 1969 by seven small high schools in Sheboygan and Ozaukee Counties in east central Wisconsin.^[1] Five members were previously in the Eastern Wisconsin Conference (Cedar Grove, Elkhart Lake-Glenbeulah, Howards Grove, Kohler and Oostburg), Random Lake joined after leaving the Scenic Moraine Conference and Ozaukee High School in Fredonia acquired their first conference affiliation since opening two years prior. The recently opened John F. Kennedy Prep in St. Nazianz joined a year later,^[2] but their stay in the conference was short-lived. The Catholic high school was removed from the Central Lakeshore Conference in 1973 because of violations against rules on student transfers.^[3] The Central Lakeshore Conference's membership roster would remain relatively stable for a quarter century with the only change being a short stint in the conference for Stockbridge from 1979^[4] to 1981.^[5] In 1999, two private high schools in Sheboygan (Sheboygan Christian and Sheboygan Lutheran) would join as part of the WIAA/WISAA merger.^[6] Stockbridge rejoined the Central Lakeshore in 2007 for the final eight years of the conference's run.^[7] In 2015, all members of the Central Lakeshore Conference with the exception of Stockbridge joined with five members of the Olympian Conference (Hilbert, Manitowoc Lutheran, Mishicot, Reedsville and St. Mary Catholic in Neenah) to form the fourteen-member Big East Conference.^[8]