Celine Marmion

Celine J. Marmion
Alma materUniversity of Surrey (PhD)
Kingston University (PGCE)
Scientific career
InstitutionsSt Mary's University, Twickenham
Royal College of Surgeons in Ireland

Celine J. Marmion is a Professor of Chemistry at the Royal College of Surgeons in Ireland and President of the Institute of Chemistry of Ireland. She is a Fellow of the Royal Society of Chemistry and the Institute of Chemistry of Ireland. Marmion is involved with the design of new chemotherapeutic drugs.

Early life and education

Marmion earned her doctoral degree at the University of Surrey in 1994.[1] Her PhD research involved investigations into vanadium complexes and nitrogen fixation. In 1994 Marmion was appointed as a lecturer at St Mary's University, Twickenham, where she worked until 1995.[2] She returned to study in 1995, and earned a Postgraduate Certificate in Education (PGCE) at Kingston University.[3]

Research and career

In 1997 Marmion joined Royal College of Surgeons in Ireland as a lecturer in the Department of Chemistry.[2] She was promoted to Associate Professor in 2013 and Professor in 2018. Her research considers the design of metal-based chemotherapeutic drugs. In particular, this has included the design of targeted PtIV prodrugs.[4][5] Immunodeficient cancer patients are at risk of developing infections, which occasionally require antimicrobial prophylaxis. To better serve these patients Marmion developed a family of metallo-antibiotics, based on a Cu-N,N-framework, which can bind to DNA, has DNA oxidant properties and has antiproliferative and antimicrobial properties.[6] Her research has been supported by the Science Foundation Ireland (SFI) to create a prodrug strategy for multi-modal chemotherapeutics.[7]

Awards and honours

Her awards and honours include:

Selected publications

Her publications include:

  • Marmion, Celine (2019). Metal-based Anticancer Agents. Royal Society of Chemistry. ISBN 9781788014069.
  • Marmion, Celine J. (2004). "Hydroxamic Acids− An Intriguing Family of Enzyme Inhibitors and Biomedical Ligands". European Journal of Inorganic Chemistry. 2004 (15): 3003–3016. doi:10.1002/ejic.200400221.
  • Marmion, Celine J. (2000). "Hydroxamic acids are nitric oxide donors. Facile formation of ruthenium(II)-nitrosyls and NO-mediated activation of guanylate cyclase by hydroxamic acids". Chemical Communications (13): 1153–1154. doi:10.1039/B001631O.

References

  1. ^ Dublin, T. U. "TU Dublin News". www.dit.ie. Retrieved 13 January 2020.
  2. ^ a b "Dr Celine Marmion – Biography". www.ucd.ie. Retrieved 13 January 2020.
  3. ^ a b "Profile". www.rcsi.com. Retrieved 13 January 2020.
  4. ^ a b Kenny, Reece G.; Chuah, Su Wen; Crawford, Alanna; Marmion, Celine J. (2017). "Platinum(IV) Prodrugs – A Step Closer to Ehrlich's Vision?". European Journal of Inorganic Chemistry. 2017 (12): 1596–1612. doi:10.1002/ejic.201601278. ISSN 1099-0682.
  5. ^ Kenny, Reece G.; Marmion, Celine J. (23 January 2019). "Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?". Chemical Reviews. 119 (2): 1058–1137. doi:10.1021/acs.chemrev.8b00271. ISSN 0009-2665. PMID 30640441. S2CID 58630540.
  6. ^ Ude, Ziga; Kavanagh, Kevin; Twamley, Brendan; Pour, Milan; Gathergood, Nicholas; Kellett, Andrew; Marmion, Celine J. (18 June 2019). "A new class of prophylactic metallo-antibiotic possessing potent anti-cancer and anti-microbial properties" (PDF). Dalton Transactions. 48 (24): 8578–8593. doi:10.1039/C9DT00250B. ISSN 1477-9234. PMID 30946409. S2CID 92997127.
  7. ^ Harrington, James (30 October 2018). "€3.5m investment in research commercialisation unveiled". Engineers Journal. Retrieved 13 January 2020.
  8. ^ a b c "Speakers – Celebrating Research – Past, Present, Future – Royal College Surgeons in Ireland". rcsi.ie. Retrieved 13 January 2020.
  9. ^ "RCSI Dean's Academic Award". www.rcsi.ie. Retrieved 13 January 2020.
  10. ^ inmedlogin. "Past Recipients". Irish Network of Healthcare Educators. Retrieved 13 January 2020.
  11. ^ "Annual General Meeting 2017 | Photo gallery | Institute of Chemistry of Ireland". www.chemistryireland.org. Retrieved 13 January 2020.
  12. ^ "Meet…". EuChemS Newsletters. 6 November 2019. Retrieved 13 January 2020.