The area around Carmen de Carupa was before the arrival of the Spanishconquistadors inhabited by the Muisca. The cacique of Ubaté ruled over the territories of Carmen de Carupa. The western and northern neighbouring indigenous group of Carmen de Carupa was the Muzo.
Modern Carmen de Carupa was founded on July 20, 1808 by José Joaquín Urdaneta and Doña Ventura.[2]