He made his AFL debut in the opening round of the 2011 AFL season in Geelong's thrilling one-point win over St Kilda.[2]
He went on to play one more game in the 2011 home-and-away season, missing out on the 2011 finals series. He afterwards played 18 of the 23 home-and-away season games with the Geelong Cats, securing his position as a regular for the years to come. He is the brother of Ben Guthrie, a journalist with afl.com.au.[3]
After the 2016 rookie draft, Guthrie was joined by his youngest brother Zach Guthrie at Geelong.
2022 was another strong season for Guthrie, becoming a premiership player alongside his brother in the Cats' 81-point thumping of Sydney in the 2022 AFL Grand Final. He also won his second Carji Greeves Medal alongside teammate Jeremy Cameron.
^The 2020 season was played with 17 home-and-away matches per team (down from 22) and 16-minute quarters with time on (down from 20-minute quarters with time on) due to the impact of the COVID-19 pandemic.