California Proposition 65 may refer to:

• California Proposition 65 (1986) (passed) The Safe Drinking Water and Toxic Enforcement Act of 1986. Requires public notice of products containing dangerous or carcinogenic chemicals.
• California Proposition 65 (2004) (failed) would have protected local jurisdiction revenues from state government encroachment.
• California Proposition 65 (2016) (failed) would have mandated sale of carryout (reusable tote) bags.

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