Cain is the surname of:

• Arthur Cain (1921–1999), British evolutionary biologist and ecologist
• Bill Cain (born c. 1947), American playwright and Jesuit priest
• Bill Cain (athletic director) (born 1933), American college football player and athletic director
• Blue Cain (born 2004), American basketball player
• Briscoe Cain (born 1984), American politician
• Carl Cain (1934–2024), American basketball player
• Chris Cain (born 1955), jazz and blues guitarist
• Cyril Edward Cain (1883–1963), American educator and historian
• D. Jamison Cain (1926–2010), American government official
• Dean Cain (born 1966), American actor
• Deon Cain (born 1996), American football player
• Elizabeth Cain (born 1962), Australian ice skater
• Fraser Cain, founder of the website Universe Today
• Henri Caïn (1857–1937), French playwright and librettist
• Herb Cain (1913–1982), Canadian professional ice hockey player
• Herman Cain (1945–2020), American businessman, talk show host, and candidate for the 2012 Republican presidential nomination
• Jackie Cain (1928–2014), American jazz vocalist
• James M. Cain (1892–1977), American crime writer
• John Cain (disambiguation), multiple people with the name John Cain including two former premiers of Victoria
• Johnny Cain (1908–1977), American football player, college sports coach, and administrator
• Jonathan Cain (born 1950), musician
• Joseph Hilliard Cain Sr. (1892–1962), American military officer and politician
• LeRoy E. Cain (born 1964), American aerospace engineer who worked for NASA
• Lorenzo Cain (born 1986), American baseball center fielder
• Matt Cain (born 1984), American baseball pitcher
• Matt Cain (writer), British writer and broadcaster
• Michael Cain (born 1966), American pianist and composer
• Michael Cain (footballer) (born 1994), English footballer
• Mick Cain (rugby union) (1885–1951), New Zealand rugby union player
• Myrtle Cain (1894–1980), American politician
• Noah Cain (born 2000), American football player
• Nyoshia Cain (born 1994), Trinidad and Tobago Paralympic athlete
• Patrick Cain (born 1962), American football player
• Paul Cain (author) (1928–1966), American writer
• Paul Cain (minister) (1929–2019), American Pentecostal minister
• Randy Cain (1945–2009), American soul singer, member of the vocal group The Delfonics
• Robert Henry Cain (1909–1974), British soldier, recipient of the Victoria Cross
• Ross Cain (1957–2011), Nauruan politician
• Roy Franklin Cain (1906–1998), Canadian bryologist and mycologist—see Coniochaetaceae
• Stanley A. Cain (1902–1995), American botanist and plant ecologist
• Stephen Cain (born 1984), Australian decathlete—see List of decathlon national champions (men)
• Susan Cain (born 1968), American non-fiction writer and lecturer
• Syd Cain (1918–2011), British production designer
• Tim Cain, American video game programmer
• Tyler Cain (born 1988), American basketball player

• Caine (surname)
• Kain (surname)
• Kane (surname)
• Cayne (disambiguation)

Surname list

This page lists people with the surname Cain.
If an internal link intending to refer to a specific person led you to this page, you may wish to change that link by adding the person's given name(s) to the link.