Cadmium resistance transporter

Cadmium Resistance Protein
Identifiers
SymbolCadD
PfamPF03596
InterProIPR004676
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

The cadmium resistance (CadD) protein family (TC# 2.A.77) belongs to the Lysine exporter (LysE) superfamily.[1] CadD members facilitate the export of cationic compounds such as cadmium ions.[2]

Members

Currently, many sequenced proteins comprise the CadD family. Two are close orthologues in two Staphylococcus species that have been reported to function in cadmium resistance, a fourth has been reported to function in quaternary ammonium cation export, and the fourth is a distant open reading frame (ORF) in Staphylococcus aureus.[3] These proteins are found in Gram-positive bacteria. Their mode of energy coupling has not been investigated, but is hypothesized to include a proton antiport mechanism. This family is distantly related to members of the LysE family (TC #2.A.75) and the RhtB family (TC #2.A.76). These three families, which are included in the LysE superfamily, all consist of proteins of similar sizes (about 200 residues) and topologies (6 putative transmembrane α-helical segments; 5 experimentally determined TMSs).[4]

General Transport Reaction

The probable reaction catalyzed by these proteins is:[2]

Cationic compound (in) + nH+ (out) → Cationic compound (out) + nH+ (in).

Further reading

References

  1. ^ Tsu BV, Saier MH (2015-01-01). "The LysE Superfamily of Transport Proteins Involved in Cell Physiology and Pathogenesis". PLOS ONE. 10 (10): e0137184. Bibcode:2015PLoSO..1037184T. doi:10.1371/journal.pone.0137184. PMC 4608589. PMID 26474485.
  2. ^ a b "2.A.77 The Cadmium Resistance (CadD) Family". Transporter Classification Database. Retrieved 2016-02-25.
  3. ^ Crupper SS, Worrell V, Stewart GC, Iandolo JJ (July 1999). "Cloning and expression of cadD, a new cadmium resistance gene of Staphylococcus aureus". Journal of Bacteriology. 181 (13): 4071–5. doi:10.1128/JB.181.13.4071-4075.1999. PMC 93898. PMID 10383976.
  4. ^ Cao Y, Jin X, Levin EJ, Huang H, Zong Y, Quick M, Weng J, Pan Y, Love J, Punta M, Rost B, Hendrickson WA, Javitch JA, Rajashankar KR, Zhou M (May 2011). "Crystal structure of a phosphorylation-coupled saccharide transporter". Nature. 473 (7345): 50–4. Bibcode:2011Natur.473...50C. doi:10.1038/nature09939. PMC 3201810. PMID 21471968.

As of 25 February 2016, this article is derived in whole or in part from Transporter Classification Database, authored by Saier Lab Bioinformatics. The copyright holder has licensed the content in a manner that permits reuse under CC BY-SA 3.0 and GFDL. All relevant terms must be followed. The original text was at "2.A.77 The Cadmium Resistance (CadD) Family"


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