COXFA4L3
| COXFA4L3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | COXFA4L3, FOAP-11, NMES1, chromosome 15 open reading frame 48, MIR147BHG, MISTRAV, MOCCI, C15orf48, Cytochrome C Oxidase Associated Subunit FA4L3 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 608409; MGI: 3034182; GeneCards: COXFA4L3 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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Cytochrome c oxidase associated subunit FA4L3 is a protein that in humans is encoded by the gene COXFA4L3 (previously C15orf48).[5] It participates in an immunoregulatory response.[6] More specifically, in response to inflammation signaling, the protein COXFA4L3 replaces the COXFA4 subunit in Cytochrome c oxidase, reducing cellular respiration in the mitochondria.[6]
Function
This gene was first identified in a study of human esophageal squamous cell carcinoma tissues. Levels of both the message and protein are reduced in carcinoma samples. In adult human tissues, this gene is expressed in the esophagus, stomach, small intestine, colon and placenta. Alternatively spliced transcript variants that encode the same protein have been identified.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000166920 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033213 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: Chromosome 15 open reading frame 48". Retrieved 2017-10-09.
- ^ a b "Q9C002 · CX4L3_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-07-28.
Further reading
- Zhou J, Wang H, Lu A, Hu G, Luo A, Ding F, Zhang J, Wang X, Wu M, Liu Z (2002). "A novel gene, NMES1, downregulated in human esophageal squamous cell carcinoma". Int. J. Cancer. 101 (4): 311–6. doi:10.1002/ijc.10600. PMID 12209954.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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