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CNKSR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WWV
Identifiers
Aliases	CNKSR1, CNK, CNK1, connector enhancer of kinase suppressor of Ras 1
External IDs	OMIM: 603272; MGI: 2670958; HomoloGene: 4604; GeneCards: CNKSR1; OMA:CNKSR1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	26,189,884 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	133,965,710 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; right lobe of thyroid gland; ; right uterine tube; ; left lobe of thyroid gland; ; body of pancreas; ; mucosa of transverse colon; ; minor salivary glands; ; olfactory zone of nasal mucosa; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	muscle of thigh; ; triceps brachii muscle; ; vastus lateralis muscle; ; temporal muscle; ; gastrocnemius muscle; ; knee joint; ; sternocleidomastoid muscle; ; medial head of gastrocnemius muscle; ; digastric muscle; ; tibialis anterior muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity; protein binding;
Cellular component	cytoplasm; plasma membrane; cell cortex; membrane; cell-cell junction;
Biological process	Ras protein signal transduction; Rho protein signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	10256
	194231
	ENSG00000142675
	ENSMUSG00000028841
	Q969H4
	A2A9K7
	NM_001297647; NM_001297648; NM_006314
	NM_001081047
	NP_001284576; NP_001284577; NP_006305
	NP_001074516
	Wikidata
View/Edit Human	View/Edit Mouse

Connector enhancer of kinase suppressor of ras 1 is an enzyme that in humans is encoded by the CNKSR1 gene.^[5]^[6]

Function

This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.^[6]