4261
12265
ENSG00000179583
ENSMUSG00000022504
P33076
P79621
NM_001379332NM_001379333NM_001379334
NM_001243760NM_001243761NM_007575NM_001302618NM_001302619
NP_001366261NP_001366262NP_001366263
NP_001230689NP_001230690NP_001289547NP_001289548NP_031601
CIITA is a human gene which encodes a protein called the class II, major histocompatibility complex, transactivator.[5] Mutations in this gene are responsible for the bare lymphocyte syndrome in which the immune system is severely compromised and cannot effectively fight infection.[5] Chromosomal rearrangement of CIITA is involved in the pathogenesis of Hodgkin lymphoma and primary mediastinal B cell lymphoma.[6]
CIITA mRNA can only be detected in human leukocyte antigen (HLA) system class II-positive cell lines and tissues. This highly restricted tissue distribution suggests that expression of HLA class II genes is to a large extent under the control of CIITA.[7] However, CIITA does not appear to directly bind to DNA.[7] Instead CIITA functions through activation of the transcription factor RFX5.[8] Hence CIITA is classified as a transcriptional coactivator.
The CIITA protein contains an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain.[9] The protein uses GTP binding to facilitate its own transport into the nucleus.[10] Once in the nucleus, the protein acts as a positive regulator of class II major histocompatibility complex gene transcription, and is often referred to as the "master control factor" for the expression of these genes.[11][12]
CIITA expression is induced by interferon gamma, possibly assisted by other signals.[13] MHC II expression in intestinal epithelial cells is upregulated under inflammation.[13]
CIITA has been shown to interact with:
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.
Lokasi Pengunjung: 3.149.26.83