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CD38-IN-78c

CD38-IN-78c
Identifiers
  • 4-{[(1R,4R)-4-(2-methoxyethoxy)cyclohexyl]amino}-1-methyl-6-(1,3-thiazol-5-yl)quinolin-2-one
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC22H27N3O3S
Molar mass413.54 g·mol−1
3D model (JSmol)
  • CN1C2=C(C=C(C=C2)C3=CN=CS3)C(=CC1=O)NC4CCC(CC4)OCCOC
  • InChI=1S/C22H27N3O3S/c1-25-20-8-3-15(21-13-23-14-29-21)11-18(20)19(12-22(25)26)24-16-4-6-17(7-5-16)28-10-9-27-2/h3,8,11-14,16-17,24H,4-7,9-10H2,1-2H3
  • Key:VJQALSOBHVEJQM-UHFFFAOYSA-N

CD38-IN-78c is a drug which acts as a potent and selective inhibitor of the glycoprotein enzyme CD38.[1] In animal studies it boosts levels of nicotinamide adenine dinucleotide (NAD+) in tissues via inhibition of CD38 mediated breakdown of nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), and has been shown to ameliorate metabolic dysfunction associated with the aging process.[2] It also has potential therapeutic application in the treatment of Alzheimer's disease.[3]

References

  1. ^ Haffner CD, Becherer JD, Boros EE, Cadilla R, Carpenter T, Cowan D, et al. (April 2015). "Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors". Journal of Medicinal Chemistry. 58 (8): 3548–71. doi:10.1021/jm502009h. PMID 25828863. S2CID 43192793.
  2. ^ Tarragó MG, Chini CC, Kanamori KS, Warner GM, Caride A, de Oliveira GC, Rud M, Samani A, Hein KZ, Huang R, Jurk D, Cho DS, Boslett JJ, Miller JD, Zweier JL, Passos JF, Doles JD, Becherer DJ, Chini EN (May 2018). "A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline". Cell Metabolism. 27 (5): 1081–1095.e10. doi:10.1016/j.cmet.2018.03.016. PMC 5935140. PMID 29719225.
  3. ^ Roboon J, Hattori T, Ishii H, Takarada-Iemata M, Nguyen DT, Heer CD, Brenner C, Yamamoto Y, Okamoto H, Higashida H, Hori O (2021). "Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide-induced microglial and astrocytic neuroinflammation by increasing NAD". J Neurochem. 158 (2): 311–327. doi:10.1111/jnc.15367. PMC 8282715. PMID 33871064.


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