Myrow's professional career started with the independent Winnipeg Goldeyes in 1999. After spending part of three seasons in Winnipeg, he first played affiliated baseball in 2001 in the New York Yankees organization.
On May 15, 2004, the Yankees traded Myrow to the Los Angeles Dodgers for Tanyon Sturtze. Myrow made his Major League Baseball debut with the Dodgers on September 6, 2005.
He became a free agent at the end of the 2008 season and signed a minor league contract with the Chicago White Sox.[2] On June 23, 2009, Myrow was traded to the Pittsburgh Pirates for cash considerations.
In 2011, he returned to the Winnipeg Goldeyes, to play for the organization that launched his professional career. He started 2012 with the Grand Prairie AirHogs. He remained with the AirHogs in 2013 before retiring to become their hitting coach.