Nieves made his NHL debut on November 15, 2016, against the Vancouver Canucks.[4] On October 26, 2017, in his second NHL game, Nieves scored his first point and in total had three assists in a 5–2 victory over the Arizona Coyotes.[5][6]
On January 1, 2021, Nieves accepted a professional tryout invitation to attend the Tampa Bay Lightning training camp.[7][8] Nearing the conclusion of camp, on January 12, 2021, Nieves was signed to a one-year, two-way contract with the Lightning.[9] Nieves was assigned to Syracuse, but would not appear in a game during the season due to a head injury.
After retiring from hockey due to injuries, Nieves established Topline Elite Hockey to train young hockey players at City Ice Pavilion in New York City.[10]