During the Revolution the Second Continental Congress appointed Otto to establish a military hospital in Trenton, New Jersey for the treatment of smallpox. He was present during the Battle of Long Island in 1776.[2] He was also assigned to the Continental hospital at Valley Forge and located in the Uwchlan Meetinghouse.[3] Later during the Revolution, Otto was put in charge of the hospitals in Yellow Springs (in what is now Chester Springs, Pennsylvania), where he and his son treated the ill soldiers from Valley Forge.[1] Dr. Otto and his son crossed the Delaware River with General Washington and his army and surprised Hessian soldiers encamped at Trenton on the morning of December 26, 1776. He was widely respected for selflessly treating wounded and dying Hessians. There were only a smattering of casualties on the American side.
His three sons were also physicians for the Army, and assisted him as Junior Surgeon and Surgeon Mates.[1]
Otto did not retire from his Army service until the age of 70.[1]
Prior to the Revolution Otto publicly opposed the Stamp Act and also served on the Berks County Committee of Public Safety.[2]
Otto died in 1787 and was buried in Reading, Pennsylvania at the Trinity Lutheran Church (where he was a member) Cemetery.[5] Many of his surgical instruments as well as a portrait of him and his wife are in the collection of the Historical Society of Berks County in Reading.
A great-grandson, William Todd Otto, a Judge from Indiana, served in Abraham Lincoln's administration as Assistant Secretary of the Interior. According to The New York Times, Judge Otto was one of twelve men permitted at Mr. Lincoln's bedside when he died.