In 2018, Isir signed a year contract with Perseru Serui. He made his league debut on 29 April 2018 in a match against PSIS Semarang. On 9 September 2018, Isir scored his first goal for Perseru against Persipura Jayapura in the 11th minute at the Mandala Stadium, Jayapura.
He was signed for Kalteng Putra to play in Liga 2 in the 2020 season. This season was suspended on 27 March 2020 due to the COVID-19 pandemic. The season was abandoned and was declared void on 20 January 2021.[3]