Biocon Limited is an Indian biopharmaceutical company based in Bengaluru, India. It was founded by Kiran Mazumdar-Shaw in 1978.[4] The company manufactures genericactive pharmaceutical ingredients (APIs) that are sold in approximately 120 countries,[5] including the United States and Europe.[4] It also manufactures novel biologics as well as biosimilar insulins and antibodies, which are sold in India as branded formulations. Biocon's biosimilar products are also sold in both bulk and formulation forms in several emerging markets.[6]
In 1979, Biocon Became the first Indian company to manufacture and export enzymes to the US and Europe.[9]
In 1989, Unilever acquired Biocon Biochemicals Ltd. in Ireland and merges it with its subsidiary, Quest International; Biocon receives US funding for proprietary technologies.[10]
In 1994, Biocon established Syngene International as a Custom Research Company (CRC).[10]
During 1998, Unilever agrees to sell its shareholding in Biocon to the Indian promoters. Biocon becomes an independent entity.[11]
In 2001, Biocon became the first Indian company to be approved by USFDA for the manufacture of lovastatin; PlaFractor is granted a US 2001 and worldwide patent.[12]
In 2003, Biocon becomes the first company worldwide to develop human insulin on a Pichia expression system.[13]
During 2006 BIOMAb EGFR, first indigenously developed humanised monoclonal antibody for head-and-neck cancer is launched and APJ Abdul Kalam inaugurates India's Largest Biotech-Hub "Biocon Park".[14]
In 2008, Biocon acquires a 70% stake in German pharmaceutical company, AxiCorp GmbH.[15]
During 2016, Syngene set up Amgen R&D center in Bangalore.[24]
In 2017, Biocon's Insugen became the first locally manufactured biosimilar product to be approved for sale by the Malaysian drug regulator.[25]
In 2017, USFDA approves Mylan-Biocon's biosimilar for cancer drug Herceptin.[26]
During 2018, Biocon, Mylan get European Commission approval to market biosimilar insulin glargine.[27]
During 2021 Biocon Biologics and Serum Institute of India formed a joint agreement to commercialise vaccines, biological drugs, and antibody therapies together.[28] Another aspect of the deal involves Bicocon selling 15% of its biologics subsidiary to Serum Institute of India, in return for Biocon gaining access to 100 million annual doses of vaccines for a 15-year period.[28]
During 2022, Biocon Biologics bought the biosimilar assets of Viatris, for $3.34 billion.[29]
Corporate governance
Kiran Mazumdar-Shaw is an Indian entrepreneur. She founded Biocon in 1978.
Her efforts in biotechnology have drawn global recognition both for the industry in India and for Biocon and was called India's "biotech queen" by The Economist[33] and India's "mother of invention" by The New York Times.[34] She was named among Time magazine's 2010 100 most influential people in the world based not only on her contribution to the biotech industry but also because she gives back to the community.[35] Shaw features on the Forbes list of "The World's 100 Most Powerful Women"[36] and in the Financial Times "Top 50 Women in Business" list.[37]
Shaw is the recipient of several awards including the Nikkei Asia Prize, 2009 for Regional Growth,[38] Express Pharmaceutical Leadership Summit Award 2009 for Dynamic Entrepreneur, The Economic Times 'Businesswoman of the Year', the 'Veuve Clicquot Initiative For Economic Development For Asia, Ernst & Young's Entrepreneur of the Year Award for Life Sciences & Healthcare, 'Technology Pioneer' recognition by World Economic Forum and the Indian Chamber of Commerce Lifetime Achievement Award. She has received two Indian national awards—Padma Shri (1989) and Padma Bhushan (2005) for her pioneering efforts in Industrial Biotechnology.[30]
Biocon announced that Christiane Hamacher has been appointed as the CEO of Biocon Biologic India Limited, with her term having started in March 2019.[39]
On 3 December 2019, Siddharth Mittal took over from Arun Chandavarkar who retired as CEO & Joint Managing Director of Biocon.[40]
In 2021, Christiane Hamacher resigned from her position, following differences with Kiran Mazumdar-Shaw.[41]
Biocon Biologics is Biocon's biosimilar subsidiary. In 2021 Biocon and Viatris received approval to launch Semglee, an insulin glargine-yfgn injection, which is the first interchangble biosimilar for diabetes in the United States.[42] In 2021, Biocon sold 15% of Biocon Biologics to Serum Institute of India for a valuation of $4.9 billion, for which Biocon will receive access to 100 million doses of vaccines per annum for 15 years.[43] These vaccines will mainly be supplied from Serum Institute's upcoming vaccine facility in Pune, and Biocon will also have the commercialization rights of Serum Institute's vaccine portfolio, which includes the COVID-19 vaccine, for the international markets.[43] In May 2022, Viatris sold its biosimilars division to Biocon Biologics for a price of US$3.335 billion.[44]
Syngene International Ltd
Established in 1993, Syngene International Limited is a contract research and development organization (CDMO). In the CDMO space, Syngene primarily focuses on research innovation and manufacturing services for their clients.[45] The company has four divisions: drug discovery services, dedicated research centres, development devices and manufacturing.[45] Syngene works with eight of the top 10 global pharma companies and, Syngene's clients include Amgen, Zoetis, GlaxoSmithKline and Bristol Myers Squibb.[46] Syngene has been expanding its operations. Since 2020, he company has opened an R&D centre in Hyderabad, is building an API manufacturing facility in Mangalore, which is scheduled to be commissioned in 2022, and has expanded their R&D facility in Bangalore.[47] Syngene also provides biologics CDMO services.[48] In July 2022, Syngene signed a 10-year agreement with Zoetis to manufacture the drug substance for Librela (bedinvetmab), a first-in-classmonoclonal antibody used for treating osteoarthritis in dogs.[49] SynVent is Syngene's drug discovery and development platform for both small and large molecules.[50] In September 2022, Biocon divested 5.4% of its shares in Syngene International.[51]
Clinigene
Clinigene International Limited is a subsidiary on Syngene offering international pharmaceutical majors Phase I-IV clinical trials and studies for novel/generic molecules.[30]
BBPL
Biocon established Biocon Biopharmaceuticals Pvt. Ltd. (BBPL) in 2003 as a joint venture with the Cuban institute CIMAB to develop and market a range of MAbs and cancer vaccines.[30]
Biocon-AxiCorp
In 2008, Biocon acquired a majority stake of 70% in AxiCorp GmbH, a German pharmaceutical marketing company.[52]
NeoBiocon
Incorporated in January 2008, NeoBiocon FZ LLC is a research and marketing pharmaceutical company based in Abu Dhabi.[53]
Biofusion Therapeutics Limited
Incorporated in March 2021, 100% owned by Biocon.[54]
Strategic partnerships
Biocon and Amylin
In 2009, Biocon and Amylin Pharmaceuticals of the United States entered into an agreement to develop, commercialise and manufacture a novel peptide therapeutic for the potential treatment of diabetes. Amylin provides expertise in peptide hormone development, particularly in the area of phybrid technology and metabolic disease therapeutics. Biocon will utilise its expertise in recombinant microbial expression and experience in preclinical and clinical development of diabetes products to manufacture the compound.[30]
Biocon and IATRICa
In 2008, Biocon and IATRICa of the United States announced a strategic partnership to co-develop immunoconjugates for targeted immunotherapy of cancers and infectious diseases. The companies are co-developing candidate products based upon IATRICa's technology platform and Biocon's expertise in drug development, biologics manufacturing, and clinical research. The goal of this collaboration is to develop a therapeutic vaccine where the T cell-mediated immunity is enhanced and maintained against a tumor that otherwise evades immune responses. Methods of developing, characterising and scaling up of conjugated monoclonal antibody production are being currently studied.[30]
Biocon and Viatris
In 2009, Biocon signed a collaboration agreement with Viatris to develop and commercialize generic biologics. Viatris and Biocon will share development, capital, and other costs to bring products to market. Viatris will have exclusive commercialisation rights in the USA, Canada, Japan, Australia, New Zealand, EU, and European Free Trade Association countries through a profit-sharing arrangement with Biocon.[30]
Biocon and Optimer
Biocon and Optimer Pharmaceuticals, a biopharmaceutical company focused on the treatment of serious infections such as Clostridioides difficile infection (CDI), have entered into a long-term supply agreement for the commercial manufacturing of the active pharmaceutical ingredient, fidaxomicin.[4][30]
Biocon and Vaccinex
Biocon is also developing fully human antibodies BVX 10 and BVX-20 with a US antibody technology partner, Vaccinex. The partnership was initiated in 2004. BVX 10 targets TNF (Tumor Necrosis Factor) which is expressed at high levels in patients with rheumatoid arthritis. Biocon's strategic partnership with Vaccinex allows access to their proprietary human antibody platform technology, thereby providing a strong IP protection to Biocon's antibody pipeline.[4][30]
Biocon and Abraxis
In 2007, Biocon and Abraxis BioScience, Inc. entered into an agreement that helped Biocon out-license the rights to develop and market a biosimilar version of GCSF (Granulocyte Colony-Stimulating Factor) to North American and European markets.[30]
Biocon and Sandoz
In January 2018, Sandoz (a Novartis division) announced a global partnership with Biocon to develop, manufacture, and commercialize multiple biosimilars in immunology and oncology for patients worldwide.[55]
Operations
Biocon's manufacturing facilities are located at two sites in Bangalore.[30]
Biocon's R&D focuses on the entire drug development pathway – from process development to non-clinical and clinical research.[30]
County Lincoln, WashingtonGedung Pengadilan County LincolnMap of Washington highlighting County LincolnLokasi di negara bagian WashingtonLokasi negara bagian Washington di Amerika SerikatDidirikan24 November 1883Asal namaAbraham LincolnSeatDavenportKota terbesarDavenportWilayah • Keseluruhan2.339 sq mi (6.058 km2) • Daratan2.310 sq mi (5.983 km2) • Perairan29 sq mi (75 km2), 1,2%Populasi • Kepada...
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Wikipedia bahasa Punjabi Logo Wikipedia bahasa Punjabi Timur (atas) dan Wikipedia bahasa Punjabi Barat (bawah)URLpa.wikipedia.orgpnb.wikipedia.orgTipeProyek ensiklopedia internetPerdagangan ?NoRegistration (en)OpsionalLanguePunjabiPenggunaBarat: 49.360 Timur: 37.739LisensiCreative Commons Attribution-ShareAlike 3.0 dan GFDL, beragam lisensi mediaPemilikYayasan WikimediaService entry (en)24 Oktober 2008; 15 tahun lalu (2008-10-24) (Punjabi Barat) 3 Juni 2002; 21 tahun lalu (200...
Supranational court established by the Council of Europe This article is about the international court of the Council of Europe (not of the European Union). For the EU's judicial branch, see Court of Justice of the European Union. For the supreme court of the EU in matters of Union law, see European Court of Justice. European Court of Human Rights48°35′48″N 07°46′27″E / 48.59667°N 7.77417°E / 48.59667; 7.77417Established 1959 (initially) 1998 (permanent) Ju...
لمعانٍ أخرى، طالع مرآة (توضيح). مرآةمعلومات عامةصنف فرعي من مُكوِّن بصريمادةمادة فنية جزء من مصباح كهربائيجهاز بصري الاستعمال صورة معكوسة لديه جزء أو أجزاء tain (en) زجاج تعديل - تعديل مصدري - تعديل ويكي بيانات ميّز عن امرأة. مرآة تعكس مزهرية. مرآة على خزانة أدراج. م...
Park in Malmö, Sweden This article does not cite any sources. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Öresundsparken, Malmö – news · newspapers · books · scholar · JSTOR (April 2023) (Learn how and when to remove this template message) You can help expand this article with text translated from the corresponding article in Swedish. (November 2009) Cl...
Sunao Sonoda園田 直Sonoda di Schiphol pada Juli 1979 Menteri Urusan Luar NegeriMasa jabatan18 Mei 1981 – 30 November 1981Perdana MenteriZenkō SuzukiPendahuluMasayoshi ItoPenggantiYoshio SakurauchiMenteri Kesehatan dan KesejahteraanMasa jabatan19 September 1980 – 18 Mei 1981Perdana MenteriZenkō SuzukiPendahuluKunikichi SaitōPenggantiTatsuo MurayamaMenteri Urusan Luar NegeriMasa jabatan28 November 1977 – 9 November 1979Perdana MenteriTakeo FukudaMasayoshi ...
Person who makes and repairs things made of tin or other light metals A tinsmith at Old Sturbridge Village Tinware desk lamp, late 1930s, Bandelier National Monument. Made by a Civilian Conservation Corps tinsmith. Tinsmiths on the roof of Storkyrkan, Stockholm 1903 A tinsmith is a person who makes and repairs things made of tin or other light metals. The profession may sometimes also be known as a tinner, tinker, tinman, or tinplate worker; whitesmith may also refer to this profession,[1...
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English Roman Catholic priest and hagiographer (1710–1773) This article's lead section may be too short to adequately summarize the key points. Please consider expanding the lead to provide an accessible overview of all important aspects of the article. (May 2024) Alban Butler (13 October 1710 – 15 May 1773) was an English Roman Catholic priest and hagiographer. Biography Alban Butler was born in 1710, at Appletree, Aston le Walls, Northamptonshire, the second son of Simon Bu...
Echinodermata Periode Cambrian–saat ini PreЄ Є O S D C P T J K Pg N TaksonomiSuperkerajaanHolozoaKerajaanAnimaliaSuperfilumDeuterostomiaFilumEchinodermata Bruguière, 1791 Upafilum & Kelas[1]Homalozoa † Gill & Caster, 1960 Homostelea † Homoiostelea † Stylophora † Ctenocystoidea † Robison & Sprinkle, 1969 Crinozoa Crinoidea Paracrinoidea † Regnéll, 1945 Cystoidea † von Buch, 1846 Edrioasteroidea † Asterozoa Ophiuroidea Asteroidea Echinozoa Echinoidea Ho...
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1995 novel by Jack Finney From Time to Time AuthorJack FinneyLanguageEnglishGenreScience fictionPublisherSimon & SchusterPublication date1995Publication placeUnited StatesMedia typeHardcover, AudiobookPages303ISBN978-0-671-89884-7Preceded byTime and Again From Time to Time is a 1995 illustrated novel by American writer Jack Finney, and published by Simon & Schuster. The book is the sequel to Time and Again,[1] which tells the story of how Simon Morley, working ...
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