Bill Hughes (November 18, 1896 – February 25, 1963) was a baseball player for the Pittsburgh Pirates in 1921. He was a pitcher. He was born on November 18, 1896, in Philadelphia, Pennsylvania, and he died on February 25, 1963, in Birmingham, Alabama. He weighed 155 lbs when playing baseball.

Hughes pitched in 20 minor league baseball seasons for 11 teams, winning 302 minor league games.

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