Barksdale may refer to:

• Barksdale, Mississippi, an unincorporated community
• Barksdale, Texas, an unincorporated community
• Barksdale, Wisconsin, a town
  • Barksdale (community), Wisconsin, an unincorporated community
• Barksdale Air Force Base

• Alfred D. Barksdale (1892–1972), American soldier, Virginia lawyer, legislator and judge
• David Barksdale (1947–1974), American gang leader from Chicago
• Don Barksdale (1923–1993), American professional basketball player
• Ethelbert Barksdale (1824–1893), Confederate congressman, author of a bill to arm slaves, and later US Congressman
• Eugene Hoy Barksdale (1896–1926), American aviator
• James L. Barksdale (born 1943), investment fund manager, U.S. Senate candidate in Georgia (2016)
• Lance Barksdale (born 1967), Major League Baseball umpire
• Mary Barksdale (1920–1992), African-American nurse, businesswoman, and civil rights activist
• Nathan Barksdale (1961-2016), a West Baltimore drug dealer and a subject of the documentary Baltimore Chronicles Legends of the Unwired
• Rhesa Barksdale (born 1944), Senior United States Circuit Judge
• William Barksdale (1821–1863), American lawyer, politician, and Confederate general

• Amy Barksdale, a character in the animated series Daria
• Rita Barksdale, a character in the animated series Daria
• Barksdale Organization, a fictional drug dealing gang on the television series The Wire
  • Avon Barksdale, a character in The Wire played by Wood Harris
  • Brianna Barksdale, a character in The Wire played by Charlene "Michael" Hyatt
  • D'Angelo Barksdale, a character in The Wire played by Larry Gilliard, Jr.
  • Tyrell Barksdale, D'Angelo and Donette's son in The Wire

This disambiguation page lists articles associated with the title Barksdale.
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