Phfier has served as a United Methodistpastor for over 40 years.[4] Her preaching career included a five-year stint in Montevideo, Uruguay under a dictatorship, an experience which she said gave her "an understanding of the dangers of authoritarianism, which is what I see in the [Republican] party right now".[2] Along with her criticism of Donald Trump, Phifer ran on a platform of expanding Medicaid, improving public education, and supporting gun control and social justice issues such as women's and LGBTQ rights.[2][5]
Phifer had not thought about entering politics until after retiring from preaching, but decided to run for the seat vacated by Deb Lavender who was running for state Senate.[2] In 2020, Phifer defeated her Republican opponent in the general election for Missouri's 90th state House district.[6][7]
In March 2024, Phifer announced her candidacy for Missouri Secretary of State in front of the Jefferson City Missouri River Regional Library. She criticized book banning efforts in Missouri and expressed a commitment to neutral ballot language.[8] She lost the race to Denny Hoskins.[9]
Phifer had no opponents in the Democratic primary elections for the Missouri House of Representatives, winning the party nomination by default each time.
Missouri House of Representatives Election, November 3, 2020, District 90[11]